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OpenTrials
Completed

NCT Number: NCT02201121

Influences of Phenylephrine, Dopamine and Ephedrine on Stroke Volume Variation and Pulse Pressure Variation

Although induced hypertension decreased SVV and PPV,the influences of stroke volume variation and pulse pressure variation caused by phenylephrine,dopamine and ephedrine were unknown.

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Key information

Conditions

Circulation Calculated SAP Drug Dose

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to be effective parameters to predict preload responsiveness. Although induced hypertension decreases PPV and SVV, the influences of phenylephrine, dopamine and ephedrine on PPV and SVV are unknown.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Their American Society of Anesthesiologists (ASA) physical status was 1 or 2
  • Body mass index (BMI) ranged from 18 to 26
  • None of the patients had known diabetes mellitus, hypertension, cardiovascular, pulmonary, endocrinological, neurological diseases, or diseases that influenced intravascular fluid volume or balance
  • All patients had a preoperative fast for at least 8 h and routine atropine intramuscular injection

Exclusion criteria

  • Persistent arrhythmias
  • Intraoperative application of vasoactive drugs except phenylephrine, dopamine and ephedrine

Treatment and study plan

Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation

Other

This research mainly study the effect of clinical commonly used vasoconstrictor drugs on blood pressure of pressure

Primary outcomes

  1. invasive arterial blood pressure as a Measure of Safety

    Time frame: DAY 1

    if instability of circulation, stop the clinical trial

Sponsors and collaborators

Lead sponsor

Chinese PLA General Hospital

Other

Registry information

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Jul 25, 2014
Registry last updated
Jul 25, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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