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NCT Number: NCT05611502

Influence of TMS on Attention Modulation

The purpose of this study is to help understand how attention processes influence brain engagement during emotion and social cognition. The investigators also want to know if these processes are associated with drinking alcohol.

Participation includes three study visits of about 2 hours each over approximately a month. The first visit involves a magnetic resonance imaging (MRI) scan and answering survey questions. Each of the next two visits will involve a session of transcranial magnetic stimulation (TMS, a non-invasive brain stimulation technique) followed by another MRI scan.

People in the Auburn/Opelika area 19 or older are eligible to participate. People who drink alcohol and people who do not drink or don't drink very much are invited to participate.

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Key information

Conditions

Drinking, Alcohol Alcohol Drinking Alcohol-Related Disorders Behavior Binge Drinking Chemically-Induced Disorders Drinking Behavior Mental Disorders Substance-Related Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Auburn University

Auburn, Alabama, 36849, United States

Location status: Recruiting

Location contact

SCAMPI Lab

CONTACT

[email protected]

334-521-2807

Samantha J Fede, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 or Older

2A. (Drinker Group): Reports consuming 4 [if female]/ 5 [if male] or more standard drinks on one occasion at least 2 times a month AND/OR reports consuming more than 7 [if female]/ 14 [if male] standard drinks per week on average

2B. (Healthy Volunteer Group): Reports consuming 4 [if female]/ 5 [if male] or more standard drinks on one occasion less than once a month AND reports consuming less than 7 [if female]/ 14 [if male] standard drinks per week on average

Exclusion criteria

  • MRI Contraindications
  • Presence of metal in the body that would make having a 7T MRI unsafe (including facial tattoos)
  • Claustrophobia, such that individual would be unable to stay in the MRI for up to 1 hr
  • Hearing loss, including tinnitus, that might be made worse by MRI or TMS
  • TMS Contraindications
  • Has ever had a seizure, or has a family history of epilepsy
  • Taking medications or substances that lower the seizure threshold*
  • Implanted devices that are in the head or rely on physiological signals
  • History of neurological disease, such as stroke or brain tumor
  • Head injury with loss of consciousness greater than 30 minutes
  • Actively withdrawing from alcohol
  • Family history of schizophrenia or presence of psychotic symptoms

Treatment and study plan

TMS

Device

TMS will be administered in a pattern that is either excitatory or inhibitory.

Other names: Magventure MagPro

Primary outcomes

  1. Change in attention switching

    Time frame: Baseline, immediately following TMS A, immediately following TMS B

    MRI Task- analysis of behavioral data

  2. Change in sociomoral attention switching

    Time frame: Baseline, immediately following TMS A, immediately following TMS B

    MRI Task- analysis of behavioral data

  3. Change in cue reactivity

    Time frame: Baseline, immediately following TMS A, immediately following TMS B

    MRI Task- analysis of behavioral data

Secondary outcomes

  1. Change in brain activity attention switching

    Time frame: Baseline, immediately following TMS A, immediately following TMS B

    MRI Task- analysis of imaging (fMRI) data

  2. Change in brain activity during sociomoral attention switching

    Time frame: Baseline, immediately following TMS A, immediately following TMS B

    MRI Task- analysis of imaging (fMRI) data

  3. Change in brain activity during cue reactivity

    Time frame: Baseline, immediately following TMS A, immediately following TMS B

    MRI Task- analysis of imaging (fMRI) data

Study contacts

Contact information is provided by the study sponsor or research team.

SCAMPI Lab

CONTACT

[email protected]

334-521-2807

Sponsors and collaborators

Lead sponsor

Auburn University

Other

Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Registry information

Official study title

A Combined Neurofeedback- TMS Intervention for Alcohol Use Disorder - Aim 2

Acronym: TAM

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Nov 10, 2022
Registry last updated
Oct 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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