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NCT Number: NCT07663435

Influence of Superficial Parasternal Intercostal Plane Block on Internal Thoracic Artery Caliber to Facilitate Surgical Harvesting in CABG

Influence of Superficial Parasternal Intercostal Plane Block (SPIPB) on Internal Thoracic Artery (ITA) Caliber and Surgical Harvesting Efficiency in Coronary Artery Bypass Grafting (CABG)

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Key information

Conditions

Pain Management Agnosia CABG Graft Integrity Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Parasternal Block Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

22 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Faculty of Medicine ,Ain Shams University

Cairo, Cairo Governorate, Egypt

About this study

Parasternal intercostal blocks (PSB) represent a newer approach to post-sternotomy pain management. Studies suggest their effectiveness in providing postoperative analgesia , with a significant advantage being their suitability even during concurrent antiplatelet or anticoagulant therapy.In addition to its sympatholytic effects cause vasodilatation , a reduction in vascular resistance, and an increase in local blood flow . The effects are maintained up to the early postoperative period .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Age group: Adult patients from age of 22 to 65 years.
  • Sex: Both sexes
  • Patients undergoing CABG with IMA harvesting

Exclusion criteria

  • • Patients with pre-existing active bloodstream infection or systemic infection
  • Refuse consent
  • IMA graft not suitable
  • Morbidly obese (BMI > 40 )
  • Hemodynamic instability
  • Severe pulmonary disease
  • Previous thoracic surgeries (makes it difficult to harvest IMA)
  • Advanced malignancy or chronic disease with life expectancy less than six months
  • Emergency surgery

Treatment and study plan

Bupivacaine

Drug

Superficial parasternal block will be given to assess diameter of IMA by using US to assess caliber and ease of harvesting.

Primary outcomes

  1. Change in Internal Thoracic Artery (ITA) Diameter

    Time frame: Measured 15 minutes after the SPIPB injection by intraoperative ultrasound.

    Change in the diameter of the Internal Thoracic Artery (ITA) measured in millimeters (mm) after SPIPB administration.

  2. Change in Internal Thoracic Artery (ITA) Cross-Sectional Area

    Time frame: Measured 15 minutes after the SPIPB injection by Intraoperative ultrasound.

    Change in the cross-sectional area of the Internal Thoracic Artery (ITA) measured in square millimeters (mm²) after SPIPB administration.

Secondary outcomes

  1. Time Required for ITA Harvesting

    Time frame: Measured during the surgical harvesting procedure.

    Total time in minutes (min) required to harvest the Internal Thoracic Artery.

  2. Technical Difficulty of ITA Harvesting

    Time frame: Assessed by the surgeon immediately after the harvesting procedure.

    Assessed using a Technical Difficulty Scale. The scale ranges from 1 (Very Easy) to 5 (Very Difficult), where a higher score indicates a worse outcome (more difficult harvesting).

  3. Postoperative Pain Score

    Time frame: Measured at 24 hours postoperatively.

    Postoperative pain assessed using the Visual Analog Scale (VAS) for pain. The scale ranges from 0 mm (No Pain) to 100 mm (Worst Possible Pain), where a higher score indicates a worse outcome.

  4. Postoperative Opioid Consumption

    Time frame: Measured over the first 24 hours postoperatively.

    Total postoperative opioid consumption, measured in Morphine Milligram Equivalents (MME).

  5. Intraoperative Hemodynamic Stability

    Time frame: Measured during the intraoperative period.

    Incidence of significant hemodynamic instability (e.g., episodes of hypotension or hypertension requiring intervention).

Study contacts

Contact information is provided by the study sponsor or research team.

Sarah hamdy Elghareeb, MD

CONTACT

[email protected]

+201012434690

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Acronym: IMA CABG PIPB

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 23, 2026
Registry last updated
Jun 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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