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Completed

NCT Number: NCT05220371

Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage

The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects.

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Key information

Conditions

Recovery

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of Vienna, Institute of Sport Science

Vienna, 1150, Austria

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • No subjective symptoms during physical exertion
  • Stable weight and dietary behaviour
  • Body Mass Index (BMI) between 18.5 and 24.9
  • No extensive strength/endurance sports so far (less than 3 h/week)
  • No complaints during strenuous physical activity

Exclusion criteria

  • Circumstances that impair/prevent sporting activity (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis etc.)
  • Intolerance/aversion to animal protein
  • Arterial hypertension (high blood pressure) (syst > 200 mmHg and/or diast > 105 mmHg) at rest
  • Presence of insulin-dependent diabetes mellitus
  • Liver and/or kidney disease that precludes a high protein load
  • Collagen supplementation or regular intake of other dietary supplements in the last 6 months.

Treatment and study plan

Collagen

Dietary Supplement

Participants ingest 15 grams of either specific collagen peptides or Placebo daily

Concurrent training

Other

Both arms undergo a 12-week trainingintervention 3x/week

Primary outcomes

  1. Change in maximal voluntary contraction (MVC)

    Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)

    Measured by isokinetic dynamometer

  2. Change in rate of force development (RFD)

    Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)

    Measured by isokinetic dynamometer

  3. Change in countermovement jump height (CMJ)

    Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)

    Measured by force plate

  4. Change in subjective pain score

    Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)

    Measured by visual analogue scale

  5. Change in Achilles tendon cross-sectional area

    Time frame: Baseline and after 12 weeks

    Measured by ultrasound

  6. Change in Vastus Lateralis fibre length

    Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)

    Measured by ultrasound

  7. Change in collagen related blood markers

    Time frame: Baseline (pre, post, 2 hours, 24 hours, 48 hours) and after 12 weeks (pre, post, 2 hours, 24 hours, 48 hours)

    Measured by blood analysis

  8. Change in Achilles tendon echo intensity

    Time frame: Baseline and after 12 weeks

    Measured by ultrasound

  9. Change in Vastus Lateralis echo intensity

    Time frame: Baseline and after 12 weeks

    Measured by ultrasound

  10. Change in body composition parameters (fat mass, fat-free mass, extracellular mass, body cell mass)

    Time frame: Baseline and after 12 weeks

    Measured by bioelectrical impedance analysis

Sponsors and collaborators

Lead sponsor

University of Vienna

Other

Collaborators

  • Collagen Research Institute

Registry information

Official study title

Influence of Specific Collagen Peptides on Parameters of Biomechanical and Systemic Recovery After Exercise-induced Muscle Damage

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Feb 2, 2022
Registry last updated
Aug 28, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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