Influence of Sodium Bicarbonate on Time-to-exhaustion at Critical Power in Endurance Athletes

During endurance exercise in the heavy and severe intensity domains, the rate at which metabolites that have been associated with the fatigue process (e.g. Pi, ADP, H, and extracellular K) accumulate increases. possibly leading to exercise cessation. Sodium bicarbonate, as a nutritional supplement, has gained attention over the past decades, because it might delay of offset fatigue. To date, there is a controversial discussion about which delivery mode (amount and frequency) might be best in optimizing endurance performance. Since the high ion load consequent to multiple ingestions might increase plasma volume, and consequently decrease bicarbonate concentrations, single acute ingestion could be more beneficial. However, in multi-day competitions or tournaments it might be necessary to use the supplement on a daily basis. Here, the investigators aim at investigating the effects of single dose or multiple dose (on five consecutive days) administration of bicarbonate vs. placebo increases endurance performance and acid-base homeostasis in trained male endurance athletes.

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Key information

Conditions

Performance

Age range

18 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Zurich, Division of Neurology

Zurich, Canton of Zurich, 8091, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

- male

no cold or temperature at beginning or during the study
between 18 and 45 years of age
active in endurance sports (3 to 5 times per week a moderate to hart training)
non-smoker
no known cardiovascular or orthopedic problems
no known limitations of kidney function
no bearer of a cardiac pacemaker
no medications with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
requirements of the health questionnaire fulfilled

Exclusion criteria

- female

male and age under 18 or over 45 years
cold or temperature at the beginning or during the study
untrained (less than 3 moderate trainings per week)
smoker
cardiovascular or orthopedic problems
limitations of the kidney function
bearer of a cardiac pacemaker
medication with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
requirements of the health questionnaire not fulfilled

Treatment and study plan

Sodium bicarbonate

Dietary Supplement

Ergogenic effect

Placebo

Dietary Supplement

Placebo effect

Primary outcomes

Time-to-exhaustion

Time frame: 5 weeks

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Collaborators

Swiss Federal Institute of Technology

Registry information

Important dates

Study start: 2011
Primary completion: 2012
Study completion: 2013
First posted: Jun 15, 2012
Registry last updated: Apr 12, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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