Influence of Reward and Punishment on Goal-directed and Habit Learning in Adolescent Anorexia Nervosa

Inclusion criteria

AN Group:

• Between the ages of 13 and 17 years old
• Meet DSM-V criteria for AN-R or AN-BP
• Medically stable per American Academy of Pediatrics and the Society of Adolescent Medicine requirements, at least 75% adjusted ideal body weight, but still symptomatic as assessed by the Eating Disorders Examination and clinical report
• Be at least 75% of adjusted ideal body weight

Healthy Control Group:

• Between the ages of 13 and 17 years old

Exclusion criteria

All Groups:

• Psychotic illness/other mental illness requiring hospitalization
• Current dependence on drugs or alcohol defined by DSM IV criteria. Additionally, positive test results for drug use on the day of the scan, apart of marijuana, will result in cancelling or rescheduling the scan because acute use will impact MRI measures.
• Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight
• Neurological disorder, neurodevelopmental disorder, or history of head injury with >30 min loss of consciousness
• Any contraindication to undergoing an MRI
• Primary obsessive compulsive disorder or primary major depressive disorder

Additional Exclusion Criteria for AN Group:

• If taking other psychotropic medication, any change in dosage in the 2 weeks before scanning

Additional Exclusion Criteria for Healthy Control Group:

• Meet or met criteria for the diagnosis of any psychiatric disorder in their lifetime
• Any history of binge eating or purging behaviors, including self-induced vomiting, laxative or diuretic misuse
• Use of any psychoactive or other medication known to affect mood or concentration in the last 3 months
• Have maintained 90% to 120% ideal body weight since menarche