Influence of Perioperative Fluid Balance on Serum Concentrations of Antibiotics and Surgical Site Infections

This study evaluates antibiotic serum concentrations in correlation with perioperative fluid balance. Patients will be recruited in rectum and esophageal surgery (representative for low blood loss and restrictive fluid management) and in liver surgery (representative for high blood loss and liberal fluid management). The hypothesis is that high blood loss and liberal fluid management dilute antibiotic serum concentrations thereby potentially increasing surgical site infections.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Antibiotic Anti-bacterial Agents Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Surgical Wound Infection Wound Infection

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Medical Center of the Johannes Gutenberg-University Mainz

Mainz, Rhineland-Palatinate, 55131, Germany

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

elective surgery of rectom, esophagus or liver with indication for a central venous catheter
informed consent

Exclusion criteria

pregnancy
medical emergency
participation in another study

Treatment and study plan

Blood sampling after antibiotic administration

Procedure

Sampling of 6 x 8 mL (in sum 48 mL) via the central venous line (established for the surgical procedure) until postoperative day 2

Primary outcomes

Serum concentration of antibiotic

Time frame: 2 days

ug/mL

Secondary outcomes

Surgical wound infection

Time frame: 30 days

Incidence

Sponsors and collaborators

Lead sponsor

Johannes Gutenberg University Mainz

Other

Registry information

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Jan 24, 2018
Registry last updated: May 30, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed