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Completed

NCT Number: NCT04564950

Influence of Periodontitis and Coronary Heart Disease on Galectin-3

The aim of this study was to analyze the association between serum and salivary Galectin-3 levels in patients with periodontitis. Furthermore, the objective was to determine if the periodontitis influenced serum and salivary Galectin-3 levels

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Key information

Conditions

Periodontal Diseases Mouth Diseases Stomatognathic Diseases

Age range

30 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Messina

Messina, 98100, Italy

About this study

Healthy controls (n=38), patients with CHD (n=39), periodontitis (n=40), and a combination of periodontitis + CHD (n=38) were enrolled in the present study. The analyzed sample undergo a demographical, clinical and periodontal evaluation and serological analyses including Endothelin-1 (ET-1) and for serum and salivary Galectin-3 levels.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Presence of at least 16 teeth
  • CP with a minimum of 40% of sites with a clinical attachment level (CAL)

≥2mm and probing depth (PD) ≥4mm;

  • Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
  • Presence of ≥40% sites with bleeding on probing (BOP)

Exclusion criteria

  • Intake of contraceptives
  • Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
  • Status of pregnancy or lactation
  • Previous history of excessive drinking
  • Allergy to local anaesthetic
  • Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Treatment and study plan

Observation of serum and salivary Galectin-3 levels

Other

Observation of serum and salivary Galectin-3 levels and correlation with periodontal indices

Primary outcomes

  1. Changes of Clinical Attachment Level (mm)

    Time frame: 1-year

    Measurment of changes in Clinical Attachment Level

Sponsors and collaborators

Lead sponsor

University of Messina

Other

Registry information

Official study title

Influence of Periodontitis and Coronary Heart Disease on Galectin-3 in Serum and Saliva

Important dates

Study start
2016
Primary completion
2018
Study completion
2018
First posted
Sep 25, 2020
Registry last updated
Dec 21, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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