Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial

Inclusion criteria

• at least 18 years of age, of either sex and any race
• diagnosis of chronic rhinosinusitis with or without nasal polyposis according to the EPOS guidelines research
• Subjects should be regularly scheduled for bilateral functional endonasal endoscopic sinus surgery
• Subjects must be in good health, free of any clinically significant disease that would interfere with the study schedule or procedures or compromise his/her safety.
• Subjects must be willing to give informed consent and adhere to visit schedules, medication restrictions, and agree to perform daily diary entries.
• Nonpregnant women of childbearing potential must use a medically acceptable, adequate form of birth control.

Exclusion criteria

• Women must not be pregnant, breast feeding, or premenarcheal.
• Subjects who have required oral corticosteroids within the previous four weeks prior to surgery.
• Subjects who have required nasal corticosteroids within the previous one week prior to surgery.
• Subjects with known allergic reaction on tetracyclines, diabetes (type 1 and 2), renal insufficiency, severe liver disease, systemic diseases affecting the nose (e.g. M. Wegener), prior surgeries of the paranasal sinuses.
• Patients with the following diseases should be excluded :

• Cystic fibrosis based on positive sweat test or DNA alleles
• Gross immunodeficiency (congenital or acquired)
• congenital mucociliary problems e.g. primary ciliary dyskinesia (PCD)
• Non-invasive fungal balls and invasive fungal disease
• systemic vasculitis and granulomatous diseases
• Cocaine abuse
• Neoplasia