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Completed

NCT Number: NCT01228162

Influence of Muscle Relaxation With Rocuronium Bromide During General Anaesthesia on Muscle Trauma and Postoperative Analgetic Consumption in Patients With Total Hip Prosthesis Implantation

The researchers want to investigate the effects of muscle relaxation with rocuronium bromide during general anaesthesia on muscle trauma (serum CK, CRP) and postoperative analgesic consumption in patients with total hip prosthesis replacement (general vs. spinal anaesthesia).

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Key information

Conditions

Muscle Relaxation Analgetic Consumption Muscle Trauma Total Hip Replacement

Age range

55 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Klinikum Hildesheim GmbH

Hildesheim, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient agreement
  • indication for total hip replacement
  • age 55 - 80 years
  • weight 65 - 95 kg
  • first intervention
  • ASA classification I - III
  • general and spinal anaesthesia possible in this patient

Exclusion criteria

a) neuromuscular diseases b) surgery with muscle trauma (within the last 3 months) c) permanent immobility d) intramuscular injections (within the last 4 weeks) e) medication with opioids f) medication with co-analgetics g) contraindications for general or spinal anaesthesia h) dementia, cognitive dysfunction or sleep apnea

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Treatment and study plan

effect of muscle relaxation on muscle trauma, control group without relaxation

Procedure

effect of muscle relaxation on muscle trauma, control group without relaxation

Primary outcomes

  1. degree of muscle trauma

    Time frame: 24 hours

    serum CK and CRP levels are measured

Secondary outcomes

  1. consumption of analgetics

    Time frame: 3 days

    consumption of piritramide is measured

Sponsors and collaborators

Lead sponsor

Klinikum Hildesheim GmbH

Other

Collaborators

  • Hannover Medical School

Registry information

Important dates

Study start
2010
Primary completion
2013
Study completion
2013
First posted
Oct 26, 2010
Registry last updated
Jun 25, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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