Skip to main content
OpenTrials
Completed

NCT Number: NCT02635139

Influence of Meal Skipping on Macronutrient Oxidation and Glucose Metabolism Under Isocaloric Conditions

Aim of the study is to investigate the impact of meal skipping (breakfast or dinner skipping) on the regulation of glucose metabolism and macronutrient balance (protein/fat/carbohydrate intake vs. -oxidation). An isoenergetic diet with 3 conventional meals (breakfast, lunch, dinner) serves as a control.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy Behavior Fasting Feeding Behavior Intermittent Fasting

Age range

20 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute of Nutritional Medicine, University of Hohenheim

Stuttgart, 70599, Germany

About this study

The duration of the study is 7 days including 3 days with controlled diet and 4 days (including 5 nights) in a metabolic chamber at the Institute of Nutritional Medicine at the University of Hohenheim.

The study phase in the metabolic chamber consists of (i) 1 day with 3 meals/day = baseline day, (ii) 1 day with breakfast skipping, (iii) 1 day with dinner skipping, (iv) 1 washout day where the subjects leave the chamber between 7 a.m. until 7 p.m..

Beginning on the 3rd study day macronutrient and energy intake as well as the fasting periods are kept constant. To achieve comparable conditions the washout day is setted before the baseline day.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy
  • not obese (BMI<30)

Exclusion criteria

  • food allergy
  • smoking
  • alternative nutrition habits
  • chronic disease
  • regular medication intake
  • claustrophobia

Treatment and study plan

Breakfast Skipping

Behavioral

18h fasting period in the morning

Dinner skipping

Behavioral

18h fasting period in the evening

Primary outcomes

  1. Regulation of glucose metabolism (substrate oxidation and insulin sensitivity)

    Time frame: 1 day

Secondary outcomes

  1. Actigraphy-assessed sleep quality

    Time frame: 1 day

  2. cardio vascular risk (lipid profile, arterial stiffness, autonomic function)

    Time frame: 1 day

Sponsors and collaborators

Lead sponsor

University of Hohenheim

Other

Registry information

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Dec 18, 2015
Registry last updated
Apr 25, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.