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Completed

NCT Number: NCT03590756

Influence of Mango Intake of Skin Health in Postmenopausal Women

This study aims to investigate the effects on 16 weeks of mango intake on skin health in postmenopausal women. Half of the participants will receive 85g portions of mangoes while the other half receive 250g portions of mangos. Participants will be instructed to consume the specific portion 4 times a week, for a total duration of 16 weeks.

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Key information

Age range

50 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Ragle Human Nutrition Research Center

Davis, California, 95616, United States

About this study

Mangoes are rich in carotenoids, flavonoids, vitamins and other active phytochemicals such as resistant starches. Although a role of mangoes in skin health has long been advocated in traditional medicine, little scientific research has been conducted.

We hypothesize that 85g (0.5 cups) of mango intake for 16 weeks will have minimal impact on skin health, while 250g (1.5 cups) of mango intake will produce significant benefits.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Postmenopausal
  • Fitzpatrick skin type I and II
  • BMI 18.5 - 35.0 kg/m2
  • Normal blood levels in the comprehensive metabolic panel, or values slightly out of range as approved by the study physician

Exclusion criteria

  • Allergic to mangoes
  • Fruit consumption of 2 or more cups per day
  • Vegetable consumption of 3 or more cups per day for females
  • Fruit juice consumption of more than 1 cup per day
  • Self-reported malabsorption
  • Currently taking regular prescription drugs i.e. statins, thyroid, anti-inflammatory drugs
  • Had any medical or cosmetic procedures such as laser resurfacing or plastic surgery to the face within the last 6 months, including botulinum toxin, dermal fillers, collagen or other similar cosmetic procedure
  • Autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos)
  • Smoking (current smoker, smoked within the past year, former smokers with greater than a 20 pack-year history of smoking within the past 20 years.
  • Indications of substance or alcohol abuse
  • Unwillingness to discontinue high antioxidant supplements during washout and interventions

Treatment and study plan

16 weeks mango intake

Other

Participants will be provided fresh frozen Ataulfo mangoes.

Primary outcomes

  1. Skin Wrinkle Depth and Redness

    Time frame: 0, 8, and 16 week

    Using a skin camera from BrighTex Bio-Photonics to measure change in skin wrinkle depth and redness within a period of 16 weeks.

  2. Skin carotenoid

    Time frame: 0, 4, 8, 12, and 16 weeks

    Using a skin photometer (Veggie Meter) to measure change in skin carotenoid within a period of 16 weeks.

Secondary outcomes

  1. Sebum

    Time frame: 0, 8, 16, weeks

    Sebum will be collected with sebutapes from the face and stored for possible further analysis.

  2. Plasma carotenoid

    Time frame: 0, 8, 16 weeks.

    Plasma samples will be collected and stored at -80C for possible further analysis

Sponsors and collaborators

Lead sponsor

University of California, Davis

Other

Collaborators

  • National Mango Board

Registry information

Official study title

Influence of Mango Intake on Skin Health in Postmenopausal Women

Acronym: MSS

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Jul 18, 2018
Registry last updated
Oct 14, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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