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OpenTrials
Completed

NCT Number: NCT04324398

Influence of Intra-Canal Cryotherapy on Post-Endodontic Pain and Interleukin-6 Expression Using Different Irrigation Protocols: A Randomized Clinical Trial

the study was to evaluate the effect of intra-canal cryotherapy on post-endodontic pain and interleukin-6 expression in teeth with symptomatic apical periodontitis using different irrigation protocols.

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Key information

Conditions

Symptomatic Periapical Periodontitis Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ahmed

Port Said, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Anterior or premolar single canal in single rooted teeth.
  • Patients aged 20 to 50 years.

Exclusion criteria

  • Patients under anti-inflammatory medication, immune-suppressive chemotherapy or any antibiotic medication for the last 2 months.
  • Pregnant or lactating females.
  • Teeth with endo-perio lesions.

Treatment and study plan

Cryotherapy

Other

cold application

Primary outcomes

  1. PAIN

    Time frame: one week

    post-operative pain is measured by using visual analogue scale (VAS) The modified VAS will include a 10 cm straight horizontal line numbered at each centimeter with following criteria: (0) for no pain, (1-3) for mild pain, (4-6) for moderate pain, (7-9) for severe tolerable pain and (10) for severe intolerable pain

Sponsors and collaborators

Lead sponsor

Suez Canal University

Other

Collaborators

  • Dalia Fayyad
  • Nelly AbdElsalam

Registry information

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Mar 27, 2020
Registry last updated
Mar 27, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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