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NCT Number: NCT07468825

Influence of Individual Traits on Adaptation Processes in Individuals With Alcohol Use Disorder

Alcohol Use Disorder (AUD) is a chronic condition that affects behavior, decision-making, and the ability to adapt to changing situations. While many studies have examined AUD from medical and social perspectives, less is known about how individual psychological traits influence the way people with AUD respond to uncertainty and adapt their behavior.

This study aims to better understand how personal characteristics such as anxiety, self-esteem, sensitivity to reward and punishment, perfectionism, and cognitive abilities may influence adaptation processes in individuals with AUD.

Participants receiving usual care at Paul Brousse Hospital will be invited to take part in a single experimental session lasting about 45 minutes. During this session, they will complete:

* A computerized learning task in which they respond to visual stimuli and receive feedback on their performance * Standardized questionnaires assessing psychological traits and cognitive functioning

The learning task is designed to evaluate how participants adjust their behavior when the rules of the task change unexpectedly. Researchers will measure how performance changes in response to uncertainty and examine how these changes relate to individual psychological characteristics.

This research does not modify participants' medical care and involves no medication or invasive procedures.

By improving understanding of the cognitive and behavioral mechanisms involved in Alcohol Use Disorder, the study may help advance scientific knowledge about how individuals adapt to uncertainty and inform future research in addiction and mental health.

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Key information

Conditions

Alcohol Use Disorder Alcohol-Related Disorders Alcoholism Behavior Behavior, Addictive Chemically-Induced Disorders Cognition Disorders Compulsive Behavior Impulsive Behavior Mental Disorders Neurocognitive Disorders Substance-Related Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

Alcohol Use Disorder (AUD) is associated with difficulties in decision-making and behavioral adaptation, particularly in situations involving uncertainty. Individual psychological traits may influence how people with AUD adjust their behavior when facing changing environments, but this relationship remains insufficiently understood.

This monocentric, non-interventional study aims to explore how individual traits influence adaptive processes in adults diagnosed with Alcohol Use Disorder.

Participants receiving usual care at Paul Brousse Hospital will attend a single experimental session lasting approximately 45 minutes. During this session, they will perform a computerized learning task designed to evaluate behavioral adaptation when task rules change unexpectedly. They will also complete standardized questionnaires assessing personality traits and cognitive functioning.

Behavioral performance during the task will be analyzed to measure adaptation to uncertainty and examined in relation to individual psychological characteristics.

The study does not involve medication, medical devices, or any modification of clinical care.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older
  • Patients receiving care for Alcohol Use Disorder at the Psychiatry and Addiction Unit of Paul Brousse Hospital
  • No objection to participation in the study

Exclusion criteria

  • Diagnosed neurological disorder
  • Patient covered by State Medical Assistance (AME)
  • Individuals under legal protection measures (guardianship, curatorship, or legal safeguard)
  • Individuals deprived of liberty by judicial or administrative decision
  • Pregnant or breastfeeding women
  • Psychiatric disorders that could compromise proper study participation (excluding Alcohol Use Disorder)

Treatment and study plan

Primary outcomes

  1. Uncertainty Cost Index During Behavioral Adaptation Task

    Time frame: At the end of the learning phase and at the beginning of the uncertainty phase during the single study session (approximately 45 minutes)

    Uncertainty cost index. Exploration-exploitation behaviors are inferred from the percentage of correct responses obtained during the CHEAT phase of the computerized task. For each participant, the difference in accuracy rate between the end of the learning phase and the beginning of the CHEAT phase is calculated. This difference (Δ) defines the uncertainty cost index and reflects exploratory behavioral responses to the introduction of misleading feedback.

Secondary outcomes

  1. Correlation Between Uncertainty Cost Index and Psychometric Trait Scores

    Time frame: During the single study session (approximately 45 minutes)

    Correlation coefficient between the uncertainty cost index and standardized psychometric test scores assessing personality traits and cognitive characteristics.

Study contacts

Contact information is provided by the study sponsor or research team.

Catherine MARTELLI, Dr

CONTACT

[email protected]

145593372 ext. +33

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Registry information

Acronym: TIPA

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Mar 13, 2026
Registry last updated
Mar 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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