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Completed

NCT Number: NCT00298597

Influence of G-CSF and EPO on Associative Learning and Motor Skills

In the study we want to prove whether the subcutaneous application of granulocyte-stimulating factor (G-CSF) and erythropoetin (EPO) influence associative learning and/or motor skills of patients, who suffer from chronic stroke or amyotrophic lateral sclerosis. The study hypothesis is that G-CSF and EPO improve associative learning and/or motor skills.

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Key information

Conditions

Chronic Stroke Amyotrophic Lateral Sclerosis Central Nervous System Diseases Metabolic Diseases Motor Neuron Disease Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases Nutritional and Metabolic Diseases Proteostasis Deficiencies Spinal Cord Diseases TDP-43 Proteinopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Department of neurology, University Hospital of Muenster

Münster, North Rhine-Westphalia, D-48149, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of chronic stroke or amyotrophic lateral sclerosis

Exclusion criteria

  • leucocytes > 10000/µl
  • hematocrit > 48%
  • thrombocytes < 150000/µl
  • severe rheumatoid arthritis
  • severe infection
  • severe liver or renal failure
  • severe arterial hypertension
  • recurrent thromboembolic events
  • severe coronary heart disease
  • myocardial infarction
  • malignant tumor
  • leukemia
  • peripheral arterial occlusion disease

Treatment and study plan

granulocyte - colony stimulating factor (G-CSF)

Drug

erythropoetin (EPO)

Drug

Primary outcomes

  1. Learning success in a word learning model

  2. Response time in motor function tests

Secondary outcomes

  1. Response time in a word learning model

  2. Total time and number of keystrokes in motor function tests

Sponsors and collaborators

Lead sponsor

University Hospital Muenster

Other

Registry information

Important dates

Study start
2006
Primary completion
2009
Study completion
2009
First posted
Mar 2, 2006
Registry last updated
Apr 23, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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