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Completed

NCT Number: NCT01354847

Influence of Extracorporeal Circulation on Platelet Function of Patients Undergoing Cardiac Surgery

This study is planned to investigate the relationship between duration of extracorporeal circulation and the extent of (acquired) platelet dysfunctions in patients undergoing cardiac surgery.

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Key information

Conditions

Acquired Platelet Function Disorder

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Goethe - University

Frankfurt am Main, Hesse, 60322, Germany

About this study

Patients undergoing complex cardiac surgery are planned to be included. At several intra- and postoperative measuring point, blood is drawn for multiple electrode aggregometry to investigate ex-vivo platelet aggregation as a surrogate for platelet function.

Transfusion rate of allogenic blood products as well as postoperative blood loss is planned to be recorded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • duration of extracorporeal circulation > 120 min

Exclusion criteria

  • pregnancy

Treatment and study plan

Multiple electrode aggregometry analyses (Multiple Electrode Aggregometry, Multiplate(R), Verum Diagnostica, Munich, Germany)

Device

ex vivo platelet aggregation at several intraoperative and postoperative measuring points.

Primary outcomes

  1. Changes in arachidonic acid induced platelet aggregation as compared to baseline (before extracorporeal circulation)

    Time frame: Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU

    Multiple Electrode aggregometry parameters

Secondary outcomes

  1. Changes in Adenosin Diphosphate (ADP) and Thrombin induced platelet aggregation as compared to baseline (before extracorporeal circulation)

    Time frame: Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU

    Multiple electrode aggregometry analyses

Sponsors and collaborators

Lead sponsor

Goethe University

Other

Registry information

Official study title

Influence of Extracorporeal Circulation on Platelet Function of Patients Undergoing Cardiac Surgery - a Prospective Observational Study

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
May 17, 2011
Registry last updated
Oct 28, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.