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Completed

NCT Number: NCT01091350

Influence of Equilibration Rate Constant (ke0) of Propofol on the Effect Site Concentration for Loss of Consciousness

The aim of this study is to validate that an effect compartment concentration for loss of consciousness (LOC) was varied according to different Keo value.

Completed

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Key information

Conditions

General Anesthesia

Age range

20 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients undergoing general anesthesia

Exclusion criteria

  • Hepatic or renal disease
  • Drug addiction

Treatment and study plan

Diprifusor (Target-controlled infusion)

Device

Two TCI devices with different Teo and same Marsh PK model

Other names: Diprifusor(Grasby Medical Limited, United Kingdom)

Orchestra (Target-controlled infusion)

Device

Two TCI devices with different Teo and same Marsh PK model

Other names: OrchestraTM (Fresenius Vial, Brezins, France)

Primary outcomes

  1. Estimated effect-site propofol concentration at loss of consciousness

    Time frame: after propofol infusion

Secondary outcomes

  1. Time to loss of consciousness

    Time frame: after propofol infusion

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

Influence of Equilibration Rate Constant (ke0) of Propofol on the Effect-site Concentration for Loss of Consciousness

Important dates

Study start
2009
Primary completion
2009
Study completion
2009
First posted
Mar 24, 2010
Registry last updated
May 31, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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