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Completed

NCT Number: NCT03342339

Influence of Emotions on Decision-making in Parkinson's Disease

Parkinson's disease mainly affects the dopaminergic neurons of the Substancia nigra, which project on the striatum. Neuronal death within this structure leads to a decrease in dopamine levels. Dopamine is a neurotransmitter essential to the proper functioning of the basal ganglia highly involved in the control of voluntary and involuntary movements.

It also leads to cognitive and behavioral changes. Among these changes, the investigators will mainly remember the idea of the emergence of difficulties to make the right decisions, for example at the financial, medical .... This disruption would be the result of executive dysfunction. By definition, executive functions allow us to evaluate, plan and organize our actions to achieve a goal.

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Key information

Age range

50 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU de Grenoble Alpes, Grenoble, France

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About this study

Some research shows that positive emotional states are associated with greater self-confidence, greater optimism, and better regulation of our decision-making. The goal is to test whether positive emotional induction could improve decision-making in Parkinson's disease.

Listening to music would decrease anxiety levels and increase self-esteem levels. Who says Parkinson says dopamine deficiency and so the investigators can think that the investigators can help patients by inducing a positive emotion through musical stimulation.

All participants will be subject to emotional induction. They will be divided into two different conditions: either they will be induced in a positive state, or they will be maintained in a neutral state. For this, video clips (positive or neutral) containing music will be presented. Immediately after the presentation of the video, participants will have to perform the Iowa Gambling Task test. This is a sequential task to evaluate decision-making capabilities.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for patients :

  • Diagnosis of the disease carried out by a hospital doctor
  • Stable treatment for two months minimum.
  • Mini-Mental Parkinson > 26
  • Under dopaminergic treatment

Exclusion criteria

for patients :

  • other neurological or psychiatric antecedents
  • anxio-depressive symptomatology
  • delusional or psychotic state

Inclusion criteria

for witnesses :

  • matched in age and sex
  • Vision and hearing normal or successfully corrected
  • Understand the French language
  • general level in the test standard

Exclusion criteria

for witnesses :

  • neurological or psychiatric diseases
  • anxio-depressive symptomatology

Treatment and study plan

cognitive examination

Other

mini mental test of Parkinson, Hospital Anxiety and Depression Scale, 5 words by Dubois, fast test frontal assessment, Trail Making Test

viewing of video

Other

viewing during 5 minutes scale of differential emotions and Positive and Negative Affect Scale

Iowa Gambling Task

Other

Test of Iowa Gambling Task

Primary outcomes

  1. net score of Iowa Gambling Task Test

    Time frame: day 1

    calculated by adding the number of cards taken in the right pile and subtracting it from the number of cards chosen in the wrong pile

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Registry information

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Nov 14, 2017
Registry last updated
Jan 19, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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