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Completed

NCT Number: NCT01005342

Influence of Dietary Fiber-rich Meals on Gene Expression and Postprandial Glucose and Lipid Response

The aim of this study is to

* Measure the effect on gene expression in leukocytes from a meal rich in oat bran * Investigate the postprandial glucose, insulin and triglyceride responses after intake of meals containing fiber from different sources (oat, rye and sugar beet fiber) or a meal containing a mixture of these three fibers

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Key information

Conditions

Hypoglycemia Glucose Metabolism Disorders Hyperglycemia Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Lund University

Lund, SE-221 00, Sweden

About this study

Dietary fiber has long been known to give beneficial health effects. Yet, the understanding of how fiber-rich meals regulate molecular events at a gene level is limited. Also, few studies have compared the effects of different fiber sources on postprandial responses and hardly any study the effects of fiber mixtures in the same meal, even though this is more similar to regular eating habits.

Healthy subjects will come to the study center after an overnight fast, to ingest breakfasts randomly enriched with different fiber. The meals contains either spray-dried oat drink, rye bran, sugar beet fiber a mixture of these three fibers, oat bran or no added fiber (control). All meals are adjusted to contain the same total amount of available carbohydrates and fat. Blood leukocytes for gene expression profiling were taken before and 2 h after consumption while blood samples for analysis of postprandial glucose, insulin and triglyceride levels were taken every 30 min during 3 h.

NuGO Affymetrix Human Genechip NuGO_Hs1a520180 are used for the microarray analysis and analysis is performed with linear mixed models and enrichment analysis to identify functional gene sets that responded to the specific oat bran effect.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI 18-30

Exclusion criteria

  • pregnancy
  • breastfeeding
  • diabetes mellitus
  • hepatitis B
  • blood lipid lowering pharmaceuticals
  • intolerance or allergy to cereals or sugar beet fiber

Treatment and study plan

Oat bran

Other

82 g oat bran was added to 250 ml blackcurrant beverage with pulp to give 5 g soluble fiber (12.6 g total fiber).

Other names: Oats, Beta-glucan

Spray-dried oat drink

Other

62 g spray-dried oat drink was added to 250 ml blackcurrant beverage with pulp to give 2.7 g soluble fiber (3.3 g total fiber).

Other names: Oats, Oat milk, Beta-glucan

Rye bran

Other

31 g rye bran was added to 250 ml blackcurrant beverage with pulp to give 1.7 g soluble fiber (12 g total fiber).

Other names: Rye, Arabinoxylan

Sugar beet fiber

Other

19 g sugar beet fiber was added to 250 ml blackcurrant beverage with pulp to give 5 g soluble fiber (12 g total fiber).

Other names: Sugar beet, Pectin

Mixture of fiber

Other

38 g spray-dried oat drink, 30 g rye bran and 6 g sugar beet fiber were added to 250 ml blackcurrant beverage with pulp to give 5 g soluble fiber (18 g total fiber).

Control

Other

No fiber was added to control meal (250 g black-currant beverage)

Primary outcomes

  1. Changed gene expression profile by fiber-rich meals

    Time frame: 2 h after meal intake

Secondary outcomes

  1. Lowering of postprandial glucose by fiber-rich meals

    Time frame: 0-180 min after meal intake

Sponsors and collaborators

Lead sponsor

Lund University

Other

Collaborators

  • Danisco Sugar AB/Fibrex
  • Lantmannen Food R&D
  • Oatly AB
  • Vinnova

Registry information

Official study title

The Influence of Dietary Fibre-rich Meals on Gene Expression in Leukocytes and Postprandial Glucose and Lipid Response in Healthy Subjects

Important dates

Study start
2007
Primary completion
2007
Study completion
2007
First posted
Oct 30, 2009
Registry last updated
Oct 30, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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