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OpenTrials
Completed

NCT Number: NCT03174223

Influence of Deep Versus Moderate Neuromuscular Blockade During General Anesthesia on 30-day Readmission Rates

Deep neuromuscular block (NMB) has shown to produce superior surgical conditions during various abdominal and non abdominal surgeries. It is however unknown if the application of deep NMB leads to favourable outcome, such as lower rate of postoperative complications in general and surgical infections in specific and ultimately lower readmission rates. In the leiden university medical center, deep NMB is routinely applied for a variety of procedures, most notably laparoscopic abdominal and retroperitoneal surgery, eye surgery and neuro radiologic intervention surgery, since 2014. This retrospective study intends to investigate whether the application of deep NMB for these procedures affects patient outcome and readmission rates.

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Key information

Conditions

Postoperative Complications Infections Lung Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Postoperative Wound Infection Respiratory Tract Diseases Respiratory Tract Infections Surgical Wound Infection Wound Infection

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Leiden University Medical Center

Leiden, 2333ZA, Netherlands

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • deep neuromuscular block
  • moderate neuromuscular block
  • general anesthesia
  • complete anesthesia chart

Exclusion criteria

  • incomplete anesthesia chart
  • missing data regarding postoperative complications or readmission

Treatment and study plan

deep neuromuscular block

Drug

a continuous dosing of rocuronium is used to achieve neuromuscular block of 1-2 twitches post tetanic count

Primary outcomes

  1. Readmission

    Time frame: 30 days after surgery

    readmission to the hospital

Secondary outcomes

  1. Cost

    Time frame: 30 days after surgery

    The total cost, including sugammadex use and readmission cost

Sponsors and collaborators

Lead sponsor

Leiden University Medical Center

Other

Collaborators

  • Merck Sharp & Dohme LLC

Registry information

Official study title

Influence of Deep Versus Moderate Neuromuscular Blockade During General Anesthesia on 30-day Readmission Rates: A Retrospective Analysis of Patient Chart Data

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Jun 2, 2017
Registry last updated
Sep 17, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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