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Completed

NCT Number: NCT03416088

Influence of Daily Activities on Retinal Microcirculation

The daily behaviors such as drinking coffee, wine, reading, exercise and body postural changes may have influence on the function or morphology of the retinal microcirculation in healthy people.A recent study found that the fingertips microvascular bed constricted obviously after the intake of a cup of coffee with caffeine, it significantly reduced blood flow to the fingers; Long reading of electronic products can induce significant dry eye symptoms, affect visual quality, and cause asthenopia. Microcirculation is critical for regulating vascular resistance and blood flow in organs. Fundus blood vessels is the only visible microvascular in vivo, its morphology and function changes not only associated with eye disease, but also with cardiovascular and cerebrovascular diseases. Optical coherence tomography angiography (OCTA) is a new technique which could acquire blood flow information in a non-invasive way without the use of dye. Magnetic resonance imaging (MRI) can quantitatively evaluation of cerebral blood flow and retina-choroid blood flow using the noninvasive arterial spin labeling technique in a large field of view (FOV) without depth limitations.The study tried to detect the influence of daily behaviors such as drinking coffee, red wine, reading , exercise, etc. on the retinal microcirculation with OCTA and MRI, and provide reference for health behaviors.

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Key information

Conditions

Retinal Microcirculation Disorder

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Shanghai Eye Disease Prevention & Treatment Center

Shanghai, Shanghai Municipality, 200040, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults
  • The age range was from 18 to 35 years old
  • Without another eye disease besides ametropia
  • The spherical equivalent is equal or above minus 3.00 diopters
  • No smoking or drinking
  • Average daily caffeine consumption no more than 1 cup of coffee
  • No diabetes, hypertension, heart disease, liver or kidney dysfunction
  • No medication taken recently

Exclusion criteria

  • Mental disorders such as depression and anxiety
  • Intellectual disabilities
  • Female in menstruation, gestation period, perinatal period or lactation period
  • Unable to cooperate with eye examinations and test procedures
  • Heart disease, hypertension, diabetes, liver and kidney dysfunction and other chronic diseases
  • Patients with fever, acute infectious diseases
  • Other conditions that are not suitable for drinking alcohol or coffee, such as allergic to alcohol or coffee

Treatment and study plan

Beverage consumption

Behavioral

The participants drink 300ml wine (alcohol concentration:12.5%)or 300ml coffee (caffeine concentration 72 mg), or water.

Daily reading

Behavioral

Reading paper books, playing video games with mobile phones, or non-reading for 8 hours.

Body motion

Behavioral

Exercise or body postural changes

Primary outcomes

  1. Vessel diameter index (VDI)

    Time frame: 3 weeks

    VDI is calculated using both the vessel area map and the skeletonized vessel map, to yield the averaged vessel caliber.

  2. Vessel area density (VAD)

    Time frame: 3 weeks

    VAD is calculated as a unit-less ratio of the total image area occupied by the vasculature to the total image area in the binary vessel maps.

  3. Flow impairment region (FIR)

    Time frame: 3 weeks

    FIZ: calculated by summing all 'no-flow' pixels up.

  4. Retina-choroid blood flow

    Time frame: 3 weeks

    Blood flow for the entire retinal thickness were determined as a function of the distance from the optic nerve head, where the blood flow was measured at the peaks of the projection profiles. An region of interest outlining the posterior retina with a size of 0.7 to 0.8 mm across the retina-choroid thickness in the parafoveal region was used to obtain the blood flow signal time courses and averaged the values.

  5. Cerebral blood flow (CBF)

    Time frame: 3 weeks

    The frontal lobe was selected as the region of interest (ROI) to measure and average the changes in CBF

Sponsors and collaborators

Lead sponsor

Jiannan Huang

Other

Registry information

Official study title

The Influence of Daily Activities on Retinal Microcirculation in Normal Adults

Important dates

Study start
2017
Primary completion
2020
Study completion
2020
First posted
Jan 30, 2018
Registry last updated
Apr 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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