University Hospital Zurich, Division of Neurology
Zurich, Canton of Zurich, 8091, Switzerland
Completed
NCT Number: NCT01905345
Influence of Consecutive Strength- and Endurance Regimes on the Myonuclear Domain and Satellite Cell in the M. Vastus Lateralis of Old Healthy Men
Randomised training intervention.
Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell
Sarcopenia
Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible.
Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.
Completed
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Notify MeKey information
Age range
18 year–75 year
Sex eligibility
Male
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
-male
- no fever at the beginning and during the study
- between 60 years and 75 years
- non smokers
- no known cardiovascular and orthopaedic problems
- no cardiac pacemaker
- fulfilling the health criteria
Exclusion criteria
-female
- fever or cold at the beginning or during the study
- non MRI compatible metal implants
- under 60 years or over 75 years
- smoker
- cardiovascular or orthopaedic problems
- cardiac pacemaker
- not fulfilling the health criteria
Treatment and study plan
Training
ProcedurePrimary outcomes
-
Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes
Time frame: participants will be followed for the duration of training period, an expected average of 7 months
Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes
Sponsors and collaborators
Lead sponsor
University of Zurich
Other
Registry information
Important dates
- Study start
- 2013
- Primary completion
- 2015
- Study completion
- 2017
- First posted
- Jul 23, 2013
- Registry last updated
- Aug 7, 2017
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.