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OpenTrials
Completed

NCT Number: NCT06163456

Influence of Cardiorespiratory Fitness and Body Composition on Resting and Post-exercise Indices of Vascular Health in Young Adults

This research is being done to determine whether acute exercise causes differences in numbers of novel blood factors associated with vascular health in college-aged adults across different physical activity habits. As only ~50% of cardiovascular (CV) events can be explained by traditional CV risk factors such as high blood pressure and high cholesterol, it is anticipated that this research will provide a more comprehensive look into novel risk factors that may better explain CV risk and that may be modifiable through regular physical activity.

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Key information

Conditions

Endothelial Dysfunction Arterial Stiffness

Age range

18 year–29 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Towson University

Towson, Maryland, 21252-0001, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-29 years of age; healthy male and female; Physically inactive, defined as participation in less than 20 min of continuous endurance exercise on fewer than 2 days/week; Recreationally active, defined as participation in 30 min/day of moderate-intensity cardiovascular activity on greater than 4 days/week; Highly active- defined as performing 30-60 min of moderate- to vigorous-intensity endurance exercise greater than 5 days/week.

Exclusion criteria

  • currently pregnant, previously diagnosed coronary heart disease or congenital heart disease, serum total cholesterol >200 mg/dl, low-density lipoprotein cholesterol >130 mg/dl, high-density lipoprotein cholesterol < 35 mg/dl, fasting glucose >100 mg/dl, systolic blood pressure > 130 mmHg, diastolic blood pressure >90 mmHg, and BMI >30 kg/m2.

Treatment and study plan

Acute submaximal exercise

Other

30 min of treadmill running at 70% of the participants maximal oxygen consumption

Primary outcomes

  1. endothelial function

    Time frame: Baseline and 60 min post-exercise

    flow-mediated dilation

  2. arterial stiffness

    Time frame: Baseline and 60 min post-exercise

    augmentation index

Sponsors and collaborators

Lead sponsor

Towson University

Other

Registry information

Important dates

Study start
2019
Primary completion
2020
Study completion
2023
First posted
Dec 8, 2023
Registry last updated
Dec 8, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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