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NCT Number: NCT03303729

Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein (ICADP)

10 young males will be recruited to participate in a randomized double blinded crossover study to investigate the influence of concomitant intake of two different types of carbohydrate with protein hydrolysate on the absorption kinetics of protein-derived amino acids and the impact on myofibrillar protein synthesis. During the trial days the subjects will perform a bout of whole body resistance exercise and ingest a supplement of meat hydrolysate labeled with D5-phenylalanine together with randomized and double blinded type of carbohydrate consisting of either glucose or cluster dextrin.

The primary outcome is the time to obtain peak concentration of D5-phenylalanine after intake of meat hydrolysate with either glucose or cluster dextrin.

Hypotheses:

I) The cluster dextrin will increase the absorption of the amino acids from the meat hydrolysate, and thereby result in a faster rise and a higher peak in plasma amino acid concentration in the postprandial period.

II) The meat hydrolysate will increase the protein synthesis rate to a higher extent when combined with cluster dextrin than with glucose.

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Key information

Conditions

Muscle Protein Synthesis Amino Acid

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Bispebjerg Hospital

Copenhagen, Copenhagen NV, 2400, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • young healthy adults,
  • organised sport/training 1-3 times per week

Exclusion criteria

  • Subject younger than 18 years or above 30 years
  • BMI > 30
  • Chronic medical diseases: active cancer, renal diseases, metabolic diseases like diabetes mellitus.
  • Physical inactivity. Subjects must participate in systematized weekly exercise 1-3 times per week.
  • Participating in systematized exercise more than 3 times per week.
  • Vegetarian.
  • Participating in a special diet which deviates from the standard of young adults.

Treatment and study plan

Meat Hydrolysate

Dietary Supplement

25 grams of meat hydrolysate to maximally stimulate protein synthesis.

Cluster Dextrin

Dietary Supplement

75 grams of Cluster Dextrin

Other names: CAS no.: 9050-36-6, Glico Nutrition Co., Ltd.

Placebo

Dietary Supplement

75 grams of Glucose

Other names: Glucose

Primary outcomes

  1. Protein hydrolysate amino acid label time to peak appearance in plasma

    Time frame: From hour 0 to hour 3

    Difference between the time to peak of protein-derived D5-phenylalanine amino acid appearance in the plasma

Secondary outcomes

  1. Myofibrillar protein fractional synthesis rate response to protein and carbohydrate intake after a whole body resistance exercise

    Time frame: from hour 0,5 to hour hour 1. From hour 1 to hour 3. From hour 0,5 to hour 3.

    Difference between myofibrillar protein fractional synthesis rate after meat hydrolysate with either 75 grams of Cluster Dextrin or Clucose.

  2. Protein hydrolysate amino acid label area under the concentration curve in plasma

    Time frame: From hour 0 to hour 3

    Difference between the area under the concentration curve of protein-derived D5-phenylalanine amino acid appearance in the plasma

  3. Insulin concentration

    Time frame: From hour 0 to hour 3

    Difference between insulin concentrations after intake of the two carbohydrate types.

Sponsors and collaborators

Lead sponsor

Bispebjerg Hospital

Other

Collaborators

  • University of Birmingham

Registry information

Official study title

Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein

Acronym: ICADP

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Oct 6, 2017
Registry last updated
Feb 27, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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