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Recruiting

NCT Number: NCT07107139

Influence of Authorized Smokeless Tobacco Product Modified Risk Claims II: Laboratory Assessment of Sensory and Subjective Effects

This study seeks to measure the effects of smokeless tobacco product risk messages on sensory experiences and future intentions to use.

Recruiting

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Key information

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Roswell Park

Buffalo, New York, 14263, United States

Location status: Recruiting

Location contact

Richard O'Connor, PHD

PRINCIPAL_INVESTIGATOR

ask rpci

CONTACT

[email protected]

877-275-7724

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 21 years of age
  • Residing in 8 counties of Western NY (Erie, Niagara, Cattaraugus, Chautauqua, Allegheny, Livingston, Genesee, Orleans, Wyoming)
  • Smoke cigarettes every day, at least 5 cigarettes per day, for at least 1 year
  • Open to trying a non-combusted oral tobacco product
  • Have the ability to read, write, and communicate in English
  • Have successfully completed our preliminary Auction study I-4008824 with a bid for Copenhagen and/or General Snus > $0
  • Willing to abstain smoking 8-10 hours prior to each laboratory session and complete breath CO test for verification (<8ppm)
  • Female participants must be amenable to taking a pregnancy test (urine) prior to beginning study procedures.
  • Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure.

Exclusion criteria

  • Age ≥ 21 years of age
  • Residing in 8 counties of Western NY (Erie, Niagara, Cattaraugus, Chautauqua, Allegheny, Livingston, Genesee, Orleans, Wyoming)
  • Smoke cigarettes every day, at least 5 cigarettes per day, for at least 1 year
  • Open to trying a non-combusted oral tobacco product
  • Have the ability to read, write, and communicate in English
  • Have successfully completed our preliminary Auction study I-4008824 with a bid for Copenhagen and/or General Snus > $0
  • Willing to abstain smoking 8-10 hours prior to each laboratory session and complete breath CO test for verification (<8ppm) .
  • Female participants must be amenable to taking a pregnancy test (urine) prior to beginning study procedures.
  • Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure.

Treatment and study plan

Copenhagen group

Other

Participants use product for up to 30 minutes

Snus group

Other

Participants use product for up to 30 minutes

Primary outcomes

  1. Change in sensory response

    Time frame: Before viewing study ads and immediatley after viewing

    assessed with a 0-100 visual analog scale - anchored by word descriptors at each end.

Secondary outcomes

  1. Change in nicotine boost

    Time frame: Will be collected after 5, 15 and 30 minutes of product use.

    Will be measured after use of products with gas chromatography-mass spectrometry

Study contacts

Contact information is provided by the study sponsor or research team.

Sponsors and collaborators

Lead sponsor

Roswell Park Cancer Institute

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 6, 2025
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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