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Completed

NCT Number: NCT00361127

Influence of Angiotensin Converting Enzyme (ACE) Genotype on Lung Diffusion in Heart Failure

In patients with chronic heart failure ACE-inhibitor treatment improves lung diffusion and prevents pulmonary edema after fluid overload. In the western country, 3 population types of ACE genotypes exist (DD, ID, II). It is unknown whether the ACE genotype influences the response to fluid overload in ACE-inhibitor treated chronic heart failure patients.

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Key information

Conditions

Heart Failure, Congestive Cardiovascular Diseases Heart Diseases Heart Failure Lung Diseases Pulmonary Edema Respiratory Tract Diseases

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centro Cardiologico Monzino

Milan, 20138, Italy

About this study

Patients with chronic heart failure in stable clinical condition treated with ACE-inhibitors, but not aspirin, will be evaluated by means of maximal cardiopulmonary exercise test and lung function including lung diffusion measurements. These tests will be done before and after rapid 500 ml isotonic saline infusion. Patients will be grouped according to their ACE genotype.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • New York Heart Association (NYHA) class I and II heart failure
  • Chronic ACE-inhibitor treatment

Exclusion criteria

  • Aspirin treatment in the previous 2 months

Treatment and study plan

isotonic saline infusion

Drug

Primary outcomes

  1. Possible identification of a genetic pattern responsible for different responses to ACE-inhibition during fluid overload in heart failure

    Time frame: Third day

Secondary outcomes

  1. Influence of ACE-genotype on exercise capacity

    Time frame: Third day

  2. Influence of ACE-genotype on lung function

    Time frame: Third day

Sponsors and collaborators

Lead sponsor

Piergiuseppe Agostoni

Other

Registry information

Official study title

Influence of ACE Genotype on Lung Diffusion at Rest and After Fluid Overload in Heart Failure Patients Treated With ACE-inhibitors

Important dates

Study start
2006
Primary completion
2013
Study completion
2013
First posted
Aug 7, 2006
Registry last updated
Jan 28, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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