Skip to main content
OpenTrials
Completed

NCT Number: NCT06526130

Influence of Anaesthesia Type on Multiple Sclerosis Relapse

The influence of anesthesia on the course of multiple sclerosis is poorly investigated and the literature is limited.

The aim of this study is to investigate multiple sclerosis relapse after different types of anesthesia.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Disease Attributes Immune System Diseases Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Recurrence

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

About this study

The influence of anesthesia on the course of multiple sclerosis is poorly investigated and the literature is limited. A possible relapse after neuraxial anesthesia, it is believed to be associated with local anesthetic's toxicity and concentration.

The aim of this study is to investigate multiple sclerosis relapse after different types of anesthesia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • multiple sclerosis
  • surgical procedure under general anaesthesia
  • surgical procedure under neuraxial anaesthesia

Exclusion criteria

  • patients (medical records) with incomplete data

Treatment and study plan

General anaesthesia

Procedure

Intravenous or volatile general anesthesia was preformed with different type of airway management (endotracheal tube, laryngeal mask and bag mask ventilation)

Neuraxial anaesthesia

Procedure

spinal or epidural injections of local anesthetic with or without opioid

Primary outcomes

  1. Multiple sclerosis relapse after 1 month

    Time frame: 1 month

    Overall incidence of multiple sclerosis relapse after 1 month after anaesthesia

  2. Multiple sclerosis relapse after 3 months

    Time frame: 3 months

    Overall incidence of multiple sclerosis relapse after 3 months after anaesthesia

  3. Multiple sclerosis relapse after 6 months

    Time frame: 6 months

    Overall incidence of multiple sclerosis relapse after 6 months after anaesthesia

  4. Multiple sclerosis relapse after 12 months

    Time frame: 12 months

    Overall incidence of multiple sclerosis relapse after 12 months after anaesthesia

Sponsors and collaborators

Lead sponsor

Varazdin General Hospital

Other

Registry information

Official study title

Multiple Sclerosis Comparison of Relapse Incidence After General and Neuraxial Anesthesia: a Retrospective Observational Study

Important dates

Study start
2012
Primary completion
2022
Study completion
2024
First posted
Jul 29, 2024
Registry last updated
Jul 30, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.