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Completed

NCT Number: NCT05505240

Influence of Ambient Temperature on Resting Energy Expenditure of Healthy Adults

The aim of this study is to investigate the influence of four different ambient temperatures (18, 22, 28, 38°C) on the resting energy expenditure of healthy adults by respiratory gas analysis. It is assumed that the resting energy expenditure is higher at 18°C and 38°C than at the temperatures in between.

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Key information

Conditions

Resting Energy Expenditure

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Bonn

Bonn, 53115, Germany

About this study

In a crossover-design, 32 healthy men and women participate in four interventions. Each intervention includes a measurement of the resting energy expenditure by respiratory gas analysis at a different ambient temperature (18,22, 28 and 38°C). During this time body core- and surface temperature are assessed, as well as body composition via bioelectrical impedance analysis. For each participant the four individual study days take place in a randomized order on consecutive weekdays within a week.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI: 18,5 - 24,9 kg/m2
  • metabolically healthy

Exclusion criteria

  • smoking
  • low or high blood pressure
  • dyslipidemia
  • insulin resistance or diabetes mellitus type 1 or type 2
  • gastrointestinal diseases (e.g. food intolerances or allergies)
  • liver, kidney and/or thyroid diseases
  • hepatitis B or C, HIV Infection
  • chronic inflammatory diseases
  • disordered eating
  • psychological diseases
  • alcohol and/or drug abuse
  • use of medication
  • pregnancy or lactating
  • participation in another intervention study
  • women: irregular menstrual cycle
  • more than 6 h of sports per week

Treatment and study plan

Respiratory analysis at cold temperature

Other

Respiratory analysis at an ambient temperature of 18°C

Respiratory analysis at room temperature

Other

Respiratory analysis at an ambient temperature of 22°C

Respiratory analysis at thermoneutral temperature

Other

Respiratory analysis at an ambient temperature of 28°C

Respiratory analysis at hot temperature

Other

Respiratory analysis at an ambient temperature of 38°C

Primary outcomes

  1. Resting Energy Expenditure

    Time frame: 20 minutes

    Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min

Secondary outcomes

  1. Body core temperature

    Time frame: 20 minutes

    Body core temperature: assessed every ten seconds during respiratory analysis (°C)

  2. Body surface temperature

    Time frame: 20 minutes

    Body surface temperature: assessed every ten seconds during respiratory analysis (°C)

  3. Body composition

    Time frame: 5 minutes (after respiratory analysis)

    assessed daily via bioelectrical impedance analysis after respiratory analysis (FFM (kg), FM (kg))

  4. Blood pressure

    Time frame: 10 minutes (at beginning of study day)

    assessed daily before respiratory analysis (mmHg)

Sponsors and collaborators

Lead sponsor

University of Bonn

Other

Collaborators

  • DLR German Aerospace Center

Registry information

Official study title

Influence of Ambient Temperature on Resting Energy Expenditure of Metabolically Healthy Men and Women

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Aug 17, 2022
Registry last updated
Apr 12, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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