Influence of Adiposity on IGF-1 and Fitness Response to Exercise in Cancer Survivors

Inclusion criteria

• Primary cancer diagnosis of breast, prostate, or colorectal cancer
• Completion of all cancer-related treatment > than 6 months prior and < 5 years prior to enrollment
• Ability and willingness to participate in a supervised exercise program

• All participants will be required to obtain a signed physician clearance to participate in exercise form prior to enrollment

Exclusion criteria

• Presence of a secondary active cancer diagnosis or metastatic disease
• Any current cancer treatment (including hormonal treatment) or planned cancer treatment in the next 5 months
• Greater than 100 min of self-reported regular exercise per week
• BMI < 18.5 (underweight)
• Any significant metabolic condition, such as diabetes. Individuals with pre-diabetes or metabolic syndrome will not be excluded, but this information will be recorded.
• Any medical condition that would impact the safety of, or participation in, an exercise program or exercise testing, including:

• Orthopedic conditions such as advanced osteoarthritis, mobility-limiting amputations or chronic injuries, or mobility-limiting acute orthopedic injuries
• Advanced rheumatoid arthritis or chronic widespread pain conditions such as fibromyalgia
• Pulmonary conditions such as chronic obstructive pulmonary disease, emphysema, or interstitial lung disease
• Known cardiovascular disease, uncontrolled hypertension, or new cardiac event within the past 6 months