Influence of Adiponutrin in Chronic Liver Disease

Increasing evidence attests the influence of multiple metabolic genetic risk factors in the progression of alcoholic liver disease. Deleterious pathways involved in metabolism such as lipid peroxidation and cytokines have been implicated in promoting inflammation leading to fibrosis increase and liver injury progression. The aim of this study was to assess the role of rs738409 single nucleotide polymorphism in the PNPLA3 gene in alcoholic liver disease patients.

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Key information

Conditions

Alcoholic Liver Disease Alcohol-Induced Disorders Alcohol-Related Disorders Chemically-Induced Disorders Digestive System Diseases Fibrosis Liver Diseases Liver Diseases, Alcoholic Pathologic Processes Pathological Conditions, Signs and Symptoms Substance-Related Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hopital Erasme- Dpt of Gastroenterology

Brussels, 1070, Belgium

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

ALD patients:

Inclusion criteria

Excess alcohol intake
Abnormal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) or a suspicion of cirrhosis related to ALD
Caucasian ethnicity

Exclusion criteria

Presence of any other chronic liver disease
Co-infection with human immunodeficiency virus

Controls:

Inclusion criteria

Caucasian ethnicity

Exclusion criteria

Presence of a disease

Treatment and study plan

Primary outcomes

Assessment of fibrosis and steatosis by liver biopsy in alcoholic liver disease patients.

After liver histology assessment for liver liver dammage a potential correlation of fibrosis and steatosis was studied with rs738409 PNPLA3 polymorphism

Sponsors and collaborators

Lead sponsor

Erasme University Hospital

Other

Registry information

Official study title

Study of Metabolism Influence in Human Alcoholic Liver Disease

Important dates

Study start: 2003
Primary completion: 2010
Study completion: 2010
First posted: May 13, 2010
Registry last updated: May 13, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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