Influence of a Single Dose Dexamethasone on the Time Course of Neuromuscular Blockade of Rocuronium

The aim of the present study is to compare the time course of a neuromuscular block in patients receiving dexamethasone 8 mg in order to reduce postoperative nausea or vomiting several hours before surgery with patients receiving the drug immediately before induction of anaesthesia and patients without a dexamethasone prophylaxis. The primary end point is the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.

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Key information

Conditions

Neuromuscular Block, Dexamethasone Neuromuscular Block, Recovery

Age range

18 year–65 year

Sex eligibility

Female

Study type

Observational

Primary location

Kreiskrankenhaus Dormagen

Dormagen, D-51375, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients aged 18 to 65 years,
American Society of Anesthesiologists Physical Status I or II,
50-90 kg body weight,
undergoing elective laparoscopic gynaecological surgery in general anaesthesia necessitating intraoperative neuromuscular blockade.

Exclusion criteria

expected difficulties with endotracheal intubation (history of difficult intubation,
reduced opening of the mouth (< 2cm), and Mallampati Score of 4),
increased risk of pulmonary aspiration (gastrooesophageal reflux, full stomach, intestinal obstruction),
known allergies to the drugs tested,
pregnancy,
neuromuscular disorders,
intake of drugs affecting neuromuscular blockade, such as furosemide, magnesium or cephalosporins,
hepatic-or renal insufficiency.

Treatment and study plan

Primary outcomes

the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.

Time frame: one hour

Sponsors and collaborators

Lead sponsor

Kreiskrankenhaus Dormagen

Other

Registry information

Important dates

Study start: 2011
Primary completion: 2013
Study completion: 2013
First posted: Feb 4, 2013
Registry last updated: Aug 17, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.