Influence of a Medicinal Cannabinoid Agonist on Responses to Food Images and Food Intake

Inclusion criteria

For healthy volunteers:

• 20 ≤ BMI ≤ 25
• Age 18-60
• Right handed
• Stable body weight for at least 3 consecutive months at start of study and no history of behavioural, therapeutic or surgical treatment aiming at or leading to weight loss/gain

For obese subjects:

• BMI > 30
• Age 18-60
• Right handed
• Stable body weight for at least 3 consecutive months at start of the study and no behavioural, therapeutic or surgical treatment aiming at or leading to weight loss/gain for at least 3 consecutive months

For FD patients:

• FD diagnosis according to 'Rome III' criteria
• Age 18-60
• Right handed
• 5% weight loss since onset of symptoms

Exclusion criteria

• Medical conditions (current or history):

• Abdominal/thoracic surgery except appendectomy
• Gastrointestinal, endocrine (especially diabetes), or neurological diseases
• Cardiovascular, respiratory, renal or urinary diseases
• Hypertension
• Food or drug allergies
• Head trauma with loss of consciousness
• Psychiatric disorders:

• Eating disorders
• Psychotic disorders
• Major depressive disorder
• Somatoform disorder
• Medication use:

• No history of cannabis use or any other drug of abuse for at least 12 months prior to the study
• All medication except oral contraception;
• Known allergy to dronabinol and/or sesam oil
• Pregnancy, plans to conceive or refusal to take adequate precaution to avoid pregnancy
• Subjects who refuse to abstain from driving during the study