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Completed

NCT Number: NCT07190924

Inflammatory Responses After CrossFit and Resistance Trainings in Untrained Subjects

Considering the remarkable increase of the fitness programs, the purpose of this study was to assess and compare the effect of Crossfit (CF) and periodized resistance (RT) trainings on inflammatory/oxidative responses in untrained individuals.

Twenty-four participants (20 men and 4 women, age= 25.7 ± 2.2 years, BMI= 25.7 kg.m-2) were randomly assigned into 12 weeks of these trainings with a rate of five sessions/week. Before and after intervention, participants anthropometric data and graded exercise tests were performed. Before (pre), immediately after (post) and 60min after test (p60) a 20mL venous blood sample were drawn for a later measure of c-reactive protein (CRP), interleukin 1 beta (IL-1ß), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 10 (IL-10), thiobarbituric acid reactive substances (TBARS), antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPx).

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Key information

Conditions

Inflammation Hormones Oxidative Stress Pathologic Processes Pathological Conditions, Signs and Symptoms Plasma Volume

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institut Supérieur du Sport et de l'Education Physique de Ksar-Saïd

Aryanah, Ariana Governorate, 2073, Tunisia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants must be non-smokers,
  • Participants should not suffer from respiratory issues
  • Participants should have healthy kidney and liver
  • Participants have no metabolic and neurological disorders

Exclusion criteria

  • The use of medications during the previous 4 weeks
  • Consumption of any product related to anti-inflammatory/oxidative supplements

Treatment and study plan

12 week training

Behavioral

Anti-inflammatory and oxidative environment following 12-weeks of CF training by evaluating inflammatory markers and oxidative precursors in untrained participants

Primary outcomes

  1. Inflammatory marker

    Time frame: Participants data were performed in one day before beginning the 12 week intervention and one day after the last session

    c-reactive protein (CRP),

  2. Inflammatory marker

    Time frame: Participants data were performed in one day before beginning the 12 week intervention and one day after the last session

    interleukin 1 beta (IL-1ß)

  3. Inflammatory marker

    Time frame: Participants data were performed in one day before beginning the 12 week intervention and one day after the last session

    tumor necrosis factor alpha (TNF-α)

  4. Inflammatory marker

    Time frame: Participants data were performed in one day before beginning the 12 week intervention and one day after the last session

    interleukin 6 (IL-6)

  5. Inflammatory marker

    Time frame: Participants data were performed in one day before beginning the 12 week intervention and one day after the last session

    interleukin 10 (IL-10)

  6. Oxidative stress

    Time frame: Participants data were performed in one day before beginning the 12 week intervention and one day after the last session

    thiobarbituric acid reactive substances (TBARS)

  7. Oxidative stress

    Time frame: Participants data were performed in one day before beginning the 12 week intervention and one day after the last session

    antioxidant enzymes catalase (CAT)

  8. Oxidative stress

    Time frame: Participants data were performed in one day before beginning the 12 week intervention and one day after the last session

    glutathione peroxidase (GPx)

Sponsors and collaborators

Lead sponsor

Habil Hamdouni

Other

Registry information

Official study title

The Effect of a CrossFit Training Program on Physical, Physiological, and Hormonal Responses in Untrained Subjects

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Sep 24, 2025
Registry last updated
Sep 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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