Inflammatory Response After One-lung Ventilation According to Ventilation Methods

Unlike conventional thoracic surgery performed under general anesthesia with tracheal intubation, non-intubated thoracic surgery with sedation and regional anesthesia has been performed recently. Non-intubated thoracic surgery is expected to reduce the postoperative inflammatory changes by maintaining more physiologic status during the operation compared to intubated thoracic surgery. The aim of this study was to compare perioperative immunological changes between intubated and non-intubated thoracic surgery.

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Key information

Conditions

Lung Cancer Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

20 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul St.Mary's Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

elective video-assisted thoracoscopic surgery (VATS) lobectomy
20 < age < 75
American Society of Anesthesiologists (ASA) classification I~II

Exclusion criteria

preoperative inflammation (CRP>10ng/㎖, WBC>10,000/mm3, body temperature >38℃)
steroid administration within 1 month
hematologic / autoimmune disease
congestive heart failure (NYHA class III~IV) or significant arrhythmia
severe obstructive / restrictive pulmonary disease
previous history of thoracic surgery
BMI >28kg/m2
expected difficult airway

Treatment and study plan

Ventilation method

Other

Depending on the group assignment, mechanical ventilation or spontaneous breathing was performed.

Primary outcomes

Interleukin (IL)-6

Time frame: 24 hours after surgery

Blood samples collected from the antecubital vein

Sponsors and collaborators

Lead sponsor

Seoul St. Mary's Hospital

Other

Collaborators

The Catholic University of Korea

Registry information

Official study title

Comparison of the Inflammatory Response After One-lung Ventilation With Positive Ventilation and Self-respiration

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Jul 5, 2019
Registry last updated: Jul 5, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed