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NCT Number: NCT03720860

Inflammatory Mediators of Acute Kidney Injury in Intensive Care

Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory response to an infection cause collateral damage to host tissue and contributes to the development of AKI. In this study we want to investigate the presence of novel inflammatory mediators in patients with sepsis, patients subjected to major surgery (sterile inflammation) and non-inflamed patients and correlate their levels with the risk for AKI.

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Key information

Conditions

Sepsis Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Infections Inflammation Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Surgery Systemic Inflammatory Response Syndrome Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Akademiska sjukhuset, Centraloperation

Uppsala, Uppsala County, 75185, Sweden

Location status: Recruiting

Location contact

Robert Frithiof, MD PhD

CONTACT

[email protected]

0736563473

Sara Bulow, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients admitted to the intensive/post operative care unit

  • with septic shock or
  • post major surgery or
  • after intoxication with a chemical compund

Exclusion criteria

  • Pregnancy or
  • Breast feeding or
  • Chronic kidney disease or
  • intoxication with nephrotoxic compund or
  • lack of informed consent

Treatment and study plan

Primary outcomes

  1. Histones

    Time frame: Within 1 month

    Correlation between levels of histones and degree of acute kidney injury

Secondary outcomes

  1. Other inflammtory mediators

    Time frame: Within 1 month

    Correlation between levels of other inflammtory mediators and degree of acute kidney injury

Study contacts

Contact information is provided by the study sponsor or research team.

Sara Bulow, MD

CONTACT

[email protected]

+46730247414

Sponsors and collaborators

Lead sponsor

Uppsala University

Other

Collaborators

  • Maastricht University

Registry information

Official study title

Prospective Studie of Inflammatory Markers in Urine, Plasma and Sputum Associated With Acute Kidney Injury

Acronym: PronMed

Important dates

Study start
2018
Primary completion
2026
Study completion
2026
First posted
Oct 25, 2018
Registry last updated
Jan 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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