Completed

NCT Number: NCT02402634

Inflammatory Gene Polymorphism and Prolonged Mechanical Ventilation After Liver Transplantation

Mechanical ventilatory lung care is essential for postoperative care in liver transplantation recipients, for such patients are under massive fluid challenge and hemodynamic alterations perioperatively. Some of the recipients experience difficulty in weaning off from the mechanical ventilator due to various causes. This study is to investigate the relationship between the inflammatory gene polymorphism, known for acute lung injury, and the duration of mechanical ventilatory care for such liver transplantation recipients.

Completed

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Key information

Conditions

Patients With Postoperative Mechanical Ventilation After Liver Transplantation

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine

Seoul, 120-752, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

20-65 years old
scheduled for liver transplantation

Exclusion criteria

Patients under mechanical ventilation prior to surgery
patients with muscular skeletal disorder, probable cause for respiratory depression
patients not able to read, or understand the consent form
ethnicity, other than asian
patients refusal

Treatment and study plan

Mechanical ventilatory lung care

Other

Primary outcomes

total duration of postoperative ventilator care

Time frame: an expected average of 2-3 days

Time for successful weaning from ventilator could correlate with the inflammtory gene polymorphism, especially those related to acute lung injury.

Sponsors and collaborators

Lead sponsor

Yonsei University