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Completed

NCT Number: NCT04120818

Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy

In this prospective study , a cohort of 58 eyes with congenital cataract from Wenzhou medical university was erolled.33 eyes with congenital cataract was after lensectomy and anterior vitrectomy as post-surger group, 26 eyes without cataract surgery as control group. The cytokines of MCP-1, VEGF, IL-1, IFN-γ, IL-1r,IL-4,IL-17, IL-2,IL-5,G-CSF,IL-12, IL-15 was evaluated

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Key information

Conditions

Congenital Cataract

Age range

10 month–72 month

Sex eligibility

All sexes

Study type

Observational

Primary location

Eye Hosptial of Wenzhou Medical College, Wenzhou, Zhejiang, China

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About this study

Secondary IOL implantation in aphika children and lensectomy and anterior vitrectomy and primary IOL implantation in children with congenital cataract were both performed by the same surgeon(Z.Y.E) and videos were collected to review the capsular reconstruction condition and lens implantation position.

Aqueous humor (100-200 μl) was aspirated from each patient before the surgery. The research was to evaluate the relationship between the cytokine profile in aqueous humor and the state of capsule after Lensectomy and Anterior Vitrectomy.Aqueous humor was obtained , Human Magnetic Luminex Screening Assay was used to determine the aqueous humor levels of cytokines.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

aphakic children diagnosed with congenital cataract who underwent secondary IOL implantation and children with congenital cataract who underwent lensectomy and anterior vitrectomy and primary IOL implantation

Exclusion criteria

patients with mild cataracts do not require surgery

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Treatment and study plan

secondary IOL implantation

Procedure

reopened the fibrotic, closed capsular bag and achieve IOL placement

primary IOL implantation

Procedure

lensectomy and anterior vitrectomy and primary IOL implantation

Primary outcomes

  1. inflammatory cytokines

    Time frame: before the surgery of secondary IOL implantation

    investigate inflammatory microenvironment changes in the aqueous of children after surgery.aqueous humor levels of cytokines, chemokines and growth factors including TGFβ2, TNF-α, IL-6, IP10, IL-10, MCP-1, VEGF, IL-1, IFN-γ, IL-1r,IL-4,IL-17, IL-2,IL-5,G-CSF,IL-12, IL-15.

Sponsors and collaborators

Lead sponsor

yin ying zhao

Other

Registry information

Official study title

Expression Profile of Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Oct 9, 2019
Registry last updated
Oct 9, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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