Infertility Markers in Serum, Urine, and Follicular Fluid

This study is only collecting specimens from current patients of PENN Fertility Care.

The purpose of this investigation is to assess if markers of oxidative stress that are known to be associated with other medical conditions can be detected in women undergoing infertility treatment and normal women of similar age. Oxidative stress may affect a woman's eggs or the follicular cells that surround and nurture them. Other markers of to be investigated include markers of cellular aging and DNA structural changes.

Presence of these markers will be compared in blood and urine samples taken during infertility treatment, and follicular fluid at the time of IVF (if applicable).

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

University of Pennsylvania Reproductive Research Unit

Philadelphia, Pennsylvania, 19104, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Women aged 18-50
Infertility patients only:

Women undergoing infertility treatment (with or without in-vitro fertilization) at the University of Pennsylvania's PENN Fertility Care
Verified infertility diagnosis of any of the following:

Endometriosis (minimal or mild)
Endometriosis (moderate or severe)
Tubal factor
Hypogonadotrophic hypogonadism
Polycystic ovary syndrome
Diminished ovarian reserve
Male factor
Unexplained
Healthy normal volunteers only:

Not undergoing infertility treatment
Not using hormonal contraception

Exclusion criteria

Currently pregnant or breastfeeding
Post-menopausal
Concurrent participation in investigational trial
Other health problems which, in the opinion of the investigator, may affect participation

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Registry information

Official study title

Markers in Women Undergoing Infertility Treatment

Important dates

Study start: 2002
Primary completion: 2012
Study completion: 2013
First posted: Sep 19, 2005
Registry last updated: Sep 30, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed