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NCT Number: NCT07008534

Inferior Alveolar Nerve Lateralization With Simultaneous Implant Placement in Atrophic Posterior Mandible

The aim of this study is to evaluate the effect of sticky bone on acceleration of recovery of the neurosensory dysfunction of the inferior alveolar nerve following inferior alveolar nerve lateralization surgery for implant placement in patients with posterior vertical bone deficiency in order to overcome the main disadvantage of this technique & provide a reliable,saving time - computer guided simultaneous implant placement- and improved technique.

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Key information

Conditions

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Lateralization of IAN allows simultaneous implant placement with longer implants and primary stability.2 IAN lateralization provides an option to avoid costly, prolonged bone graftt and also healing periods can be reduced by this option of treatment Vestibular depth remains intact as there is no augmentation in the underlying bone defect. 2 IAN lateralization technique has also some advantages such as less morbidity and less of peri-implant disease.2 In case of the IAN is located in the superior part of the body of the mandible , and presence of mild atrophy of the edentulous alveolar ridge will fetch the alveolar ridge in a close relation to the neuro-vascular bundle, The incidence of "high" IAN locations ranges from 14.6 to 30.7%. 1However there is some complications such as numbness after surgery which is considered as the most common one also prevent thermal conductivity via implants(Kahnberg et al., 2000) so sticky bone is going to be used to act as an insulator between dental imlants & Inferior alveolar nerve and it contains a number of growth factors so it is predicted to play an important role to enhance recovery of the inferior alveolar nerve after surgery

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients requiring oral rehabilitation with dental implants in vertically atrophied
  • Posterior mandibular region, less than 8mm of bone above the mandibular canal.
  • Patients should be free from any systemic conditions that may affect normal healing.
  • Absence of any pathological conditions involving mandibular bones.

Exclusion criteria

  • Patients under bisphosphonates treatment.
  • Any contraindication for general anaesthesia.
  • Osteoporotic patients.
  • Patients with neurological disorders (neuralgias, Parkinson' s disease).
  • Patients with systematic disease that may complicate healing.

Treatment and study plan

Patients receiving computer-guided immediate implant placement and inferior alveolar nerve (IAN) lateralization only.

Procedure

Standard procedure without Sticky Bone application.

IAN lateralization with computer-guided immediate implant placement using Sticky Bone

Procedure

The same as the control with additional application of Sticky Bone as an insulator for enhanced neurosensory disfunction

Primary outcomes

  1. Clinical neurosensory assessment of inferior alveolar nerve.

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Evaluation of Neurosensory Function of Inferior Alveolar Nerve Following Lateralization With Sticky Bone Versus Nil Using Computer Guided Dental Implant Placement: A Randomized Clinical Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Jun 6, 2025
Registry last updated
Jul 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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