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NCT Number: NCT07680972

Infant Diet and Caregiver Resistome

Antimicrobial resistance genes (ARGs) are the genes that allow bacteria to survive antibiotic treatments. These genes can be found in beneficial gut microbes, and occur more frequently in infants than adults. These genes can also transmit between different bacterial species. Exclusively breastfed infants carry fewer ARGs than formula fed infants. We are trying to find out if care-givers working with exclusively breastfed infants have fewer ARGs than those working with formula fed infants.

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Key information

Conditions

Professional Caregivers Working With Infants Under Age 6 Months

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Employment at a childcare facility or home daycare at time of sampling
Participant works and interacts with infants under the age 6 months old, including responsibility for changing diapers
Participant >18 years old

Exclusion criteria

Participant has a history or presence of a medical condition including Ulcerative Colitis, Crohn's Disase, Inflammatory Bowel Disease, colon cancer, Celiac's disease, or other GI disordrs
Current priobitic use or probiotic use within the last 4 weeks
Participant is currently pregnant or breastfeeding
Participant has an infant <12 months old at home for 3 or more days per week
Enrollment in a clinical trial involving an invstigational drug or dvic
Antibiotic use within the past 3 months
Participant working exclusively with infants >6 months old at time of stool sample collection

Treatment and study plan

None. Observational study

Other

We will collect stool samples and questionnaires on infant caregivers

Primary outcomes

Count of antimicrobial resistance genes (ARGs) in stool

Time frame: 2 weeks from enrollment

Count of ARGs in stool sample, and association with infant usual diet
Abundance of antimicrobial resistance genes (ARGs)

Time frame: 2 weeks from enrollment

Abundance of ARGs in stool samples from caregivers in relation to infant usual feeding practices

Secondary outcomes

Count and diversity of antimicrobial resistance genes (ARGs) and caregiver diet

Time frame: 2 weeks from enrollment

We will also test for the extent caregiver diet impacts their own carriage of ARGs
Diversity and abundance of antimicrobial resistance genes (ARGs) and interactions

Time frame: 2 weeks

Determine the extent to which caregiver type of interaction (e.g. diaper changes, cuddling infants) impacts caregiver ARGs
Caregiver gut microbiome

Time frame: 2 weeks

Determine the extent to which infant diet, caregiver diet, and infant-caregiver interactions impact the caregiver gut microbiome.

Study contacts

Contact information is provided by the study sponsor or research team.

Diana H Taft, PhD

CONTACT

[email protected]

352-294-3755

Dylan KP Blaufus, MS

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

University of Florida

Other

Registry information

Official study title

Breastfeeding and Its Impact on the Infant-caregiver Resistome

Acronym: IDCR

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2029
First posted: Jul 2, 2026
Registry last updated: Jul 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.