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OpenTrials
Completed

NCT Number: NCT03533803

Indomethacin Prior to Difficult Embryo Transfer is it a Solution?

IVF/ICSI patients who had difficult mock embryo transfer on the day of ovum pick up. Will be randomly assigned into two groups; group A will receive 100mg indomethacin rectal suppository 1-2 hours before ET and group B will not receive indomethacin

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Key information

Conditions

Difficult Embryo Transfer

Age range

20 year–38 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 3

Primary location

Nile IVF center

Giza, 12411, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Infertile patients undergoing IVF cycle with difficult mock embryo transfer
  • Early follicular FSH level ≤10 IU/L.
  • Tubal, male infertility and unexplained causes of fertility will be recruited.
  • Fresh ET.

Exclusion criteria

  • Repeated IVF failure.
  • Past history of allergy to NSAID, bronchial asthma , peptic ulcer or inflammatory bowel disease.
  • Easy mock embryo transfer.

Treatment and study plan

Indomethacin 100Mg Suppository

Drug

Indomethacin 100Mg Suppository will be given 1 to 2 hours before embryo transfer in cases with difficult mock embryo transfer in the active comparator group.

Other names: Indomethacin

IVF/ICSI

Procedure

patients received induction with the long agonist stimulation protocol. Followed by ovum pickup and embryo transfer. Only those with difficult mock embryo transfer will be recruited in this study.

Primary outcomes

  1. Implantation rate

    Time frame: 6 weeks

    the number of total gestational sacs divided by the total number of embryos transferred.

Secondary outcomes

  1. Clinical pregnancy rate

    Time frame: 6 weeks

    Presence of fetal pulsations after 2 weeks from the positive pregnancy test.

  2. Ongoing pregnancy rate

    Time frame: 12 weeks

    Pregnancies continuing beyond 12 weeks

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Collaborators

  • Nile Ivf Center, Cairo, Egypt

Registry information

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
May 23, 2018
Registry last updated
Dec 14, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.