Individualized Timing of Analgesia and Effectiveness of Labor Analgesia

Neuraxial analgesia is the gold standard to relieve labor pain. It also helps to attenuate maternal anxiety and improve maternal satisfaction. A recent "Practice guidelines for obstetric anesthesia" suggests that neuraxial analgesia should be provided in the early stage of labor (cervical dilation < 5 cm) or, for some special patients, be provided on a individualized basis. Studies showed that, when compared with late administration, early administration of labor analgesia resulted in equivocal findings for spontaneous, instrumented, and cesarean delivery. The investigators hypothesize that neuraxial labor analgesia provided on an individualized basis will further improve analgesia quality and maternal satisfaction. The purpose of this randomized controlled trial is to investigate whether neuraxial labor analgesia administered on an individualized basis can improve analgesia quality and maternal satisfaction.

Inclusion criteria

• Nulliparas (aged 18-36 years) with single cephalic term pregnancy;
• Plan to deliver vaginally, and are considered suitable for a trial of vaginal delivery by obstetricians;
• Admitted to the delivery room;
• Agree to receive epidural analgesia during labor.

Exclusion criteria

• History of psychiatric disease (indicate those that are diagnosed before or during pregnancy by psychiatrists);
• Presence of contraindications to epidural analgesia, which includes: (1) History of infectious disease of the central nervous system (poliomyelitis, cerebrospinal meningitis, encephalitis, etc.); (2) History of spinal or intra-spinal disease (trauma or surgery of spinal column, intra-spinal canal mass, etc.); (3) Systemic infection (sepsis); (4) Skin or soft tissue infection at the site of epidural puncture; (5) Coagulopathy.
• Other reasons that are considered unsuitable for study participation.