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NCT Number: NCT07473375

Indicators Affecting PVT Recanalization

This is a retrospective-prospective study conducted at Zhongshan Hospital, Fudan University, to explore portal vein thrombosis (PVT) in patients with cirrhosis and gastroesophageal varices (GEV). It aimed to provide insights into the diagnosis, follow-up, and factors influencing PVT recanalization, to help patients, families, and healthcare providers understand the disease and related clinical management.

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Key information

Conditions

Portal Vein Thrombosis Cirrhosis Digestive System Diseases Fibrosis Hypertension, Portal Liver Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Portal Hypertension Related to Cirrhosis Portal Hypertension, Noncirrhotic

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosed as cirrhosis and confirmed gastroesophageal varices by endoscopy;
  • all patients were diagnosed as PVT by CTA at admission.

Exclusion criteria

  • patients with hepatocellular carcinoma;
  • patients with extrahepatic malignancies;
  • history of liver transplantation or TIPS;
  • lack of information regarding anticoagulation therapy；
  • those with cavernous transformation of the portal vein(CTPV) .

Treatment and study plan

Primary outcomes

  1. PVT recanalization at 1 year

    Time frame: From the first abdominal imaging assessment after admission, until the occurrence of PVT recanalization at 1 year, death, or the last follow-up, whichever came first

Secondary outcomes

  1. Occurrence of all-cause death (competing event)

    Time frame: From the date of admission confirmation of PVT to the occurrence of death, or the last follow-up, whichever came first

  2. PVT recanalization at 5 years

    Time frame: From the first abdominal imaging assessment after admission, until the occurrence of PVT recanalization at 5 year, death, or the last follow-up, whichever came first

  3. Occurrence of non-improved PVT

    Time frame: From the date of admission confirmation of PVT to the last radiological follow-up at 1 year, or death, whichever came first

    defined as unchanged thrombus size, <50% thrombus reduction, or thrombus extension to new venous segments

Study contacts

Contact information is provided by the study sponsor or research team.

Siyu Jiang, Dr.

CONTACT

[email protected]

+86-15121068078

Sponsors and collaborators

Lead sponsor

Shanghai Zhongshan Hospital

Other

Registry information

Official study title

Indicators Affecting Portal Vein Thrombosis Recanalization in Cirrhosis With Gastroesophageal Varices

Important dates

Study start
2017
Primary completion
2027
Study completion
2028
First posted
Mar 16, 2026
Registry last updated
Mar 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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