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Completed

NCT Number: NCT01991704

Incubation of Alcohol Craving During Abstinence

In order to determine whether the 'incubation of craving' phenomenon also occurred in alcoholics, investigators employed an experimental approach to investigate the time course of cue-induced craving in alcoholism. Eighty male participants were randomly divided into Four groups, and they were assessed at 7, 14, 30, and 60 days of abstinence for cue-induced alcohol craving . Another group including 19 patients was repeatedly tested for the cue-induced alcohol craving at the above abstinence days. Other psychological and physiological measures were administered at the four abstinence time points.

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Key information

Conditions

Alcohol Dependence Alcohol-Related Disorders Alcoholism Chemically-Induced Disorders Mental Disorders Substance-Related Disorders

Age range

18 year–60 year

Sex eligibility

Male

Study type

Observational

About this study

All subjects provided written informed consent after a full explanation of the protocol design.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • met the criteria of DSM-IV for alcohol dependence
  • aged 18-60 years,male

Exclusion criteria

  • current or past history of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) axis I disorders
  • with other serious physical diseases (respiratory disorders, cardiovascular disease and so on)
  • other drug abuse except for nicotine

Treatment and study plan

Primary outcomes

  1. changes of alcohol craving measured with visual analogue scales

    Time frame: abstained from alcohol for 7 days, 14 days, 30 days and 60 days

Secondary outcomes

  1. heart rate changes

    Time frame: 7, 14, 30 and 60 days after abstained

  2. blood pressure changes in different abstinence days

    Time frame: 7, 14, 30 and 60 days after abstained

  3. skin conductance changes in different abstinence days

    Time frame: 7, 14, 30 and 60 days after abstained

  4. changes of Alcohol Urge Questionnaire

    Time frame: 7, 14, 30 and 60 days after abstained

Sponsors and collaborators

Lead sponsor

National Institute on Drug Dependence, China

Other

Collaborators

  • National Natural Science Foundation of China

Registry information

Official study title

The Neural Mechanisms of the Incubation of Cue-induced Craving in Alcohol Dependence

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Nov 25, 2013
Registry last updated
Nov 25, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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