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OpenTrials
Completed

NCT Number: NCT06064084

Incretin Effect in Patients With Psoriasis and Controls

To investigate the incretin effect and postprandial incretin responses in plasma in patients with psoriasis

Completed

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Key information

Conditions

Psoriasis Vulgaris

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

no diabetes BMI < 27 kg/m^2 normal Glucose tolerance test at screening normal fasting plasma glucose no islet auto antibodies no hormonel contraception informed consent psoriasis vulgaris (PASI>8) (case not controls)

Exclusion criteria

other chronic inflammtory skin disease other chronic inflammatory disease pregnancy psychiatric illness

Treatment and study plan

Oral glucose tolerance test

Diagnostic Test

Oral glucose tolerance test 50g

Intravenous isoglycaemic glucose clamp

Other

Intravenous isoglycaemic glucose clamp

Liquid Mixed meal test

Other

Liquid Mixed meal test 520 kcal

Primary outcomes

  1. Incretin effect measured with Beta-cell secretory response

    Time frame: 0-180 minutes

    Incretineffect (%) = 100 % × (Beta-cell Secretory Response (OGTT) - Beta-cell Secretory Response (IIGI)) / Beta-cell Secretory Response (OGTT)

Secondary outcomes

  1. Insulin sensitivity measures

    Time frame: 0-180 minutes

    Matsudas insulin sensitivity index: (10,000 / √glucose minute 0 x insulin minute 0) (mean glucose (OGTT) x mean insulin OGTT))

  2. Concentration of Glucose-independent insulinotropic polypeptide

    Time frame: 0-180 minutes

    Evaluted as Area Under the Curve

  3. Concentration of Glucagon-like peptide 1

    Time frame: 0-180 minuntes

    Evaluated as Area Under the Curve

  4. Concentration of Glucagon

    Time frame: 0-180 minutes

    Evaluated as Area Under the Curve

  5. Concentration of Insulin

    Time frame: 0-180 minutes

    Evaluated as Area Under the Curve

Sponsors and collaborators

Lead sponsor

University Hospital, Gentofte, Copenhagen

Other

Registry information

Official study title

Incretin Effect in Patients With Psoriasis

Important dates

Study start
2011
Primary completion
2015
Study completion
2015
First posted
Oct 3, 2023
Registry last updated
Oct 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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