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OpenTrials
Completed

NCT Number: NCT00803296

Incretin Effect in Lean and Obese Subjects

The incretin effect is markedly reduced in patients with type 2 diabetes. Data support the notion that this deficiency is a consequence of the diabetic state. However, the impact of insulin resistance on the incretin effect in obese individuals who uphold a normal glucose tolerance (NGT) despite their insulin resistant state remains to be elucidated. The primary aim of the present study is to evaluate the separate impact of one of the cornerstones of type 2 diabetic pathophysiology, namely insulin resistance, on the incretin effect in lean and obese patients with type 2 diabetes and in two matched normal-glucose tolerant groups of healthy control subjects.

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Key information

Conditions

Incretin Effect Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases Type 2 Diabetes

Age range

18 year–70 year

Sex eligibility

Male

Study type

Observational

Primary location

Gentofte Hospital, University of Copenhagen

Hellerup, Copenhagen, 2900, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with type 2 diabetes for at least 3 months
  • Normal blood hemoglobin
  • Informed consent

Exclusion criteria

  • Liver disease
  • Diabetic nephropathy
  • Treatment with medication that can not be stopped for 12 hours

Treatment and study plan

oral glucose tolerance test (OGTT)

Other

Isoglycemic intravenous glucose infusion

Other

Primary outcomes

  1. Incretin effect

    Time frame: 2 days

Secondary outcomes

  1. Insulin resistance

    Time frame: 2 days

Sponsors and collaborators

Lead sponsor

University Hospital, Gentofte, Copenhagen

Other

Registry information

Official study title

The Impact of Obesity and Insulin Resistance on the Incretin Effect in Patients With Type 2 Diabetes and Healthy Subjects

Acronym: BMI-INK

Important dates

Study start
2006
Primary completion
2008
Study completion
2008
First posted
Dec 5, 2008
Registry last updated
Jan 13, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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