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NCT Number: NCT07274306

Incidence, Treatment and Outcome After Acute Mesenteric Ischemia in the Region of Västra Götaland, 2000-2023.

The goal of this retrospective observational study is to describe the incidence and outcome of patients diagnosed with acute mesenteric ischemia (AMI) in the Västra Götaland region of Sweden between 2000-2023. The main questions it aims to answer are:

* What was the observed incidence and outcome, and how did it change during the time period? * How did socioeconomic factors influence incidence and outcome of AMI? * What main surgical approaches were selected for these patients? * What was the distribution of anticoagulant use in the cohort, and what effect did the introduction of new oral anticoagulants (NOAC) have on incidence and mortality in AMI? * What was the prevalence of Short Bowel Syndrome (SBS) after surgical intervention?

Participants were obtained from the regional diagnosis registry. Additional datapoints were obtained from the Swedish statistics bureau and pharmaceutical registers.

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Key information

Conditions

Mesenteric Artery Ischemia Cardiovascular Diseases Digestive System Diseases Gastrointestinal Diseases Intestinal Diseases Mesenteric Ischemia Peritoneal Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Sahlgrenska hospital/Östra hospital, Gothenburg, Västra Götaland County, Sweden

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Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all patients discharged from hospital with acute mesenteric ischemia (ICD K55.0 and K55.9)

Exclusion criteria

-

Treatment and study plan

Primary outcomes

  1. Incidence of acute mesenteric ischemia

    Time frame: Year 2000-2023

    Annual incidence rate of acute mesenteric ischemia per 100,000 person-years in the Västra Götaland region.

  2. Mortality from acute mesenteric ischemia

    Time frame: 30 days, 90 days, 1 year.

    All-cause mortality within up to 1 year of AMI diagnosis.

Secondary outcomes

  1. Temporal trends in incidence and mortality

    Time frame: Year 2000-2023

    Change over time in incidence and mortality, including before and after introduction of non-vitamin K antagonist oral anticoagulants (NOACs).

  2. Socioeconomic determinants of incidence and outcome

    Time frame: Year 2000-2023

    Association between SES indicators (income, education, immigration status, geographic distance to care) and risk of AMI or mortality.

  3. Surgical management strategy

    Time frame: Year 2000-2023

    Proportion of patients undergoing bowel resection, revascularization (open or endovascular), or non-operative management.

  4. Prevalence of Short Bowel Syndrome (SBS)

    Time frame: Within 1 year of surgical intervention

    Number and percentage of patients developing SBS (ICD-10 K91.2 and K90.8) after AMI.

  5. Anticoagulant use patterns

    Time frame: At AMI diagnosis; trends from 2000-2023

    Proportion of patients using vitamin-K antagonists, NOACs, antiplatelet therapy, or no anticoagulation; association with incidence and survival.

Sponsors and collaborators

Lead sponsor

Sahlgrenska University Hospital

Other

Collaborators

  • Gothia Forum - Center for Clinical Trial
  • Göteborg University

Registry information

Official study title

Incidence, Treatment of and Outcome of Acute Mesenteric Ischemia in the Region of Västra Götaland, 2000-2023 - a Retrospective Observational Study

Acronym: AMIGO

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Dec 10, 2025
Registry last updated
Dec 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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