Incidence of Viral Hepatitis D Relapses Upon Discontinuation of Bulevirtide in Patients With Chronic Hepatitis D and Negative HDV RNA

The main goal of this study is the following:

• To assess the probability of HDV relapse-free over time after discontinuation of background therapy with bulevirtide in patients with chronic co-infection with hepatitis B and D viruses and negative PCR HDV RNA

Primary endpoint: Occurrence of hepatitis D viral relapse.

Additional objectives in this study:

• Analyze data on the time of relapse and the duration of previous background therapy with bulevirtide, the duration of the period of HDV suppression, and the use of any other concomitant antiviral therapy during the period of treatment with bulevirtide
• Analyze relapse-free patients over 96 weeks of study follow-up
• Analyze the results of qualitative PCR (positive / negative) for hepatitis D virus RNA in a liver biopsy before discontinuing bulevirtide therapy

Inclusion criteria

• Informed consent of the patient to participate in the study, collect and use data
• Age 18 or older
• Background therapy with bulevirtide for at least 48 weeks
• Negative qualitative PCR test for RNA of viral hepatitis D in peripheral blood before inclusion in the study
• No active liver inflammation
• Liver biopsy performed as part of routine practice (no older than 3 weeks before inclusion in the study) or prescribed biopsy to be performed before bulevirtide interruption

Exclusion criteria

• Liver damage not related to viral hepatitis B and D - autoimmune hepatitis, drug or alcohol liver damage, Wilson-Konovalov disease, etc.
• Co-infection with hepatitis C virus
• Patients receiving HBV and HDV therapy not in accordance with standard practice or violations of the Instructions for the medical use of the drug/s
• Moderate/severe renal/liver dysfunction
• Lack of informed consent