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NCT Number: NCT07196319

"Incidence of Compensatory Hyperhidrosis After T3 Vs T3-4 Sympathectomy"

The goal of this study is to compare the proportion of compensatory hyperhidrosis patients after sympathectomy at T3 level and sympathectomy at T3-4 level. The main question it aims to answer is:

can sympathectomyv at one level decrease the incidence of compensatory hyperhidrosis after primary hyperhidrosis.

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Key information

Age range

6 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Primary hyperhidrosis is a chronic condition characterized by excessive sweating beyond physiological needs, commonly affecting the palms, axillae, face, or soles. This disorder is largely attributed to neurogenic hyperexcitability within the sympathetic nervous system's pathways innervating the eccrine sweat glands.When conservative treatments such as topical agents or oral medications fail, endoscopic thoracic sympathectomy (ETS) is considered an effective surgical option. However, a major postoperative complication is compensatory hyperhidrosis (CH)-the development of excessive sweating in previously unaffected areas such as the trunk, back, or thighs. CH can significantly impact patient satisfaction and quality of life, often becoming more distressing than the original condition.

The extent and level of sympathectomy have been proposed as key factors influencing the incidence and severity of CH. While higher levels or multilevel resections (e.g., T2-4) are associated with increased rates of CH, more limited approaches such as T3-only resection are thought to reduce this risk. However, definitive evidence comparing T3 versus T3-4 sympathectomy remains limited and inconsistent across studies.

This study aims to compare the incidence and severity of compensatory hyperhidrosis following T3 versus T3-4 sympathectomy for primary hyperhidrosis. Understanding these differences may help refine surgical approaches to minimize CH and improve patient outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with primary hyperhidrosis
  • Patients with palmar and\\or axillary hyperhidrosis.
  • Age ≥ 6 years

Exclusion criteria

  • History of Prior thoracic surgery.
  • History of prior disorder that cause hyperhidrosis ( obesity,autonomic neuropathy,menopause,gout,etc…)
  • History of prior systemic diseases cause hyperhidrosis (hyperthyroidism,DM,pheochromocytoma,Parkinson's disease,etc…)
  • Patients with psychological problems.

Treatment and study plan

Primary outcomes

  1. To compare the incidence of compensatory hyperhidrosis following T3 versus T3-4 sympathectomy.

    Time frame: 1 year post-sympathectomy

Secondary outcomes

  1. severity of Compensatory hyperhidrosis by hyperhidrosis disease severity scale

    Time frame: 1 year post sympathectomy

    • The sweating is never noticeable and doesn't interfere with daily activities.
    • The sweating is tolerable but sometimes interferes with daily activities.
    • The sweating is barely tolerable and frequently interferes with daily activities.
    • The sweating is intolerable and always interferes with daily activities.
  2. recurrence rates of primary hyperhidrosis

    Time frame: 1 year post sympathectomy

  3. site of compensatory hyperhidrosis

    Time frame: 1year post sympathectomy

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

"From One Problem to Another, Comparing the Incidence of Compensatory Hyperhidrosis After T3 Vs. T3-4 Sympathectomy"

Important dates

Study start
2025
Primary completion
2027
Study completion
2028
First posted
Sep 29, 2025
Registry last updated
Oct 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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