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NCT Number: NCT07359313

Incidence of Colon Ischemia in Patients After Cardiopulmonary Resuscitation (CPR)

Bedside colonoscopy 24-36 hours after successful CPR

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Key information

Conditions

Cardiac Arrest (CA) Cardiovascular Diseases Digestive System Diseases Gastrointestinal Diseases Heart Arrest Heart Diseases Intestinal Diseases Mesenteric Ischemia Peritoneal Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

According to previous observations, many patients after CPR develop acute non-occlusive mesenteric ischemia. However, due to the lack of established screening strategies, the number of unreported cases may be high. Routine colonoscopy at 24-36 hours after CPR may be a safe, easy and cost-effective strategy for early detection of severe mesenteric ischemia and transfer to surgical treatment. However, this strategy has not been formally evaluated in larger prospective cohorts. In our center, we perform routine colonoscopy at 24 to 36 hours after cardiac arrest in all patients who receive extracorporeal CPR (ECPR), i.e., in all patients with prolonged cardiac arrest refractory to conventional CPR measures who therefore receive venoarterial extracorporeal membrane oxygenation (VA ECMO) for cardiocirculatory support. In these patients, colonoscopy screening was feasible and safe, and our data suggest clinical benefit.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patients (≥ 18 years) admitted to the participating department AND
  • in-hospital or out-of-hospital cardiac arrest (IHCA, OHCA)

Exclusion criteria

  • resuscitation period of ≤ 5 minutes
  • awake and contactable patients (GCS ≥ 13)

Treatment and study plan

colonoscopy

Procedure

bedside colonoscopy without bowel cleansing early (24-36h) after successful CPR

Primary outcomes

  1. Detection of colon ischemia

    Time frame: from baseline (0 hours) until day 30

    Detection of colon ischemia within 30 days after return of spontaneous circulation

Secondary outcomes

  1. in-hospital mortality

    Time frame: from baseline (0 hours) until hospital discharge

    in-hospital mortality

  2. abdominal surgery ((hemi-)colectomy)

    Time frame: from baseline (0 hours) until hospital discharge

    number of patients requiring/receiving abdominal surgery ((hemi-)colectomy)

  3. functional outcome

    Time frame: day 30, day 60 and day 90

    Cerebral Performance Category (CPC)

  4. Liver function

    Time frame: within 0-72 hours after CPR

    Liver function parameters: Quick/INR, AST, ALT, AP, g-GT

  5. renal function

    Time frame: within 0-72 hours after CPR

    Renal function parameters: creatinine, BUN

  6. Urine output

    Time frame: within 0-72 hours after CPR

    Urine output (ml)

  7. Renal replacement therapy

    Time frame: from baseline (day 0) until day 30

    Implementation of renal replacement therapy within 30 days after return of spontaneous circulation

  8. Serum lactate

    Time frame: within 0-72 hours after CPR

    Serum lactate

  9. SOFA score

    Time frame: at 0 hours, 24 hours, 48 hours, 72 hours after CPR

    SOFA

  10. SAPS II score

    Time frame: at 0 hours, 24 hours, 48 hours, 72 hours after CPR

    SAPS II

Study contacts

Contact information is provided by the study sponsor or research team.

Alexander Supady, MD, MPH

CONTACT

[email protected]

+49-761-270-34010

Sponsors and collaborators

Lead sponsor

University Hospital Freiburg

Other

Registry information

Official study title

Incidence of Colon Ischemia in Patients After Cardiopulmonary Resuscitation (CPR): a Prospective Single-center Epidemiological Incidence Study

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Jan 22, 2026
Registry last updated
Jan 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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